83466-69-7Relevant academic research and scientific papers
X=Y-ZH Systems as Potential 1,3-Dipoles. Part 1. Background and Scope
Grigg, Ronald,Gunaratne, H. Q. Nimal,Kemp, James
, p. 41 - 46 (2007/10/02)
X=Y-ZH Systems are considered in general terms and divided into four classes according to the number of constituent atoms that possess lone-pair electrons.Those systems in which the central Y atom possesses a lone pair are shown to be capable of participa
Derecemization par protonation enantioselective. Application a un α-aminoacide, la phenylglycine
Duhamel, Lucette,Plaquevent, Jean-Christophe
, p. 75 - 83 (2007/10/02)
This work describes the application of deracemization by enantioselective protonation to α-aminoacid derivatives.Esters of phenylglycine are readly converted into Schiff bases.Melanation of the latter by a lithium amide, followed by protonation by a chiral acid, leads to the optically active starting materials (e.e. as high as 70percent).Chiral acids can easily be retrieved after protonation with excellent yields and conservation of enantiomeric purity.A mechanism responsible for the asymmetric induction is suggested by means of a study of the parameters modifying the selectivity, such as the nature of protecting groups, chiral acid, and lithium amide.
