83472-62-2

Basic information

• Product Name: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine
• Synonyms: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine;6-BroMo-7-chloro-3H-iMida...
• CAS NO: 83472-62-2
• Molecular Formula: C6H3BrClN3
• Molecular Weight: 232.46512
• Mol File: 83472-62-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine(83472-62-2)
• EPA Substance Registry System: 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine(83472-62-2)

Safety Data

• Hazardous Substances Data: 83472-62-2(Hazardous Substances Data)

Usage

Description

6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is a heterocyclic chemical compound with the molecular formula C7H4BrClN2. It is a member of the imidazopyridine class and is characterized by the presence of a bromine atom at the 6th position and a chlorine atom at the 7th position. 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is known for its potential applications in the pharmaceutical and chemical industries, particularly in the synthesis of pharmaceutical drugs and as a valuable component in medicinal chemistry.

Uses

Used in Pharmaceutical Synthesis:
6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and functional groups make it a versatile building block in the development of new pharmaceuticals with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is utilized for its potential to interact with biological targets and modulate their activity. Its presence in drug molecules can contribute to the desired pharmacological effects and improve the overall efficacy of the drug.
Used in Organic Synthesis:
6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is also employed in organic synthesis, where it can be used to form a variety of complex organic compounds. Its reactivity and functional groups make it a valuable precursor in the synthesis of other heterocyclic compounds and organic molecules.
Used in Chemical Research:
In the realm of chemical research, 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine serves as a model compound for studying the properties and reactions of heterocyclic compounds. Its unique structure allows researchers to explore new synthetic routes, reaction mechanisms, and potential applications in various chemical processes.
Overall, 6-Bromo-7-chloro-3H-imidazo[4,5-b]pyridine is a versatile chemical with a wide range of potential applications in the pharmaceutical and chemical industries. Its unique structure and functional groups make it an essential component in the development of new drugs, organic synthesis, and chemical research.

Upstream product

• 28279-49-4 6-bromo-3H-imidazo[4,5-b]pyridine 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 83472-57-5 6-Bromoimidazo<4,5-b>pyridine 4-Oxide 
• 83472-69-9 6-Bromo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo<4,5-b>pyridine 4-Oxide 
• 1071000-23-1 6-Bromo-1-trimethylsilanyl-1H-imidazo[4,5-b]pyridine 4-oxide 
• 83472-70-2 6-Bromo-7-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazo<4,5-b>pyridine 

Relevant articles and documents

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors

The TAM kinase family arises as a new effective and attractive therapeutic target for cancer therapy, autoimmune and viral diseases. A series of 2,6-disubstituted imidazo[4,5-b]pyridines were designed, synthesized and identified as highly potent TAM inhib

Direct Alkynylation of 3H-Imidazo[4,5-b]pyridines Using gem-Dibromoalkenes as Alkynes Source

C2 direct alkynylation of 3H-imidazo[4,5-b]pyridine derivatives is explored for the first time. Stable and readily available 1,1-dibromo-1-alkenes, electrophilic alkyne precursors, are used as coupling partners. The simple reaction conditions include an inexpensive copper catalyst (CuBr·SMe2 or Cu(OAc)2), a phosphine ligand (DPEphos) and a base (LiOtBu) in 1,4-dioxane at 120 °C. This C-H alkynylation method revealed to be compatible with a variety of substitutions on both coupling partners: heteroarenes and gem-dibromoalkenes. This protocol allows the straightforward synthesis of various 2-alkynyl-3H-imidazo[4,5-b]pyridines, a valuable scaffold in drug design.