83482-91-1Relevant academic research and scientific papers
HURAT1 (human urate anion transporter 1) inhibitors and application thereof
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Paragraph 0064; 0086; 0086; 0088, (2018/11/22)
The invention belongs to the field of medicinal chemistry and particularly relates to hURAT1 (human urate anion transporter 1) inhibitors and an application thereof. Specifically, the hURAT1 inhibitors are compounds with structure shown as formula (I) or (II) in the description or pharmaceutically acceptable salts of the compounds. Experiments prove that the compounds have good inhibition effect on uric acid transport of the hURAT1 in an HEK293 transfection cell, which shows that the compounds have good application prospect in treatment of hyperuricemia or gout.
CLEAVAGE OF THE N-N BOND IN 1-SUBSTITUTED INDAZOLES UNDER THE INFLUENCE OF ARYLLITHIUM COMPOUNDS
Tertov, B. A.,Onishchenko, P. P.,Koshchienko, Yu. V.,Suvorova, G. M.,Malysheva, E. N.
, p. 823 - 826 (2007/10/02)
Upon reaction with aryllithium compounds (phenyllithium and m-tolyllithium) m-methyl- and 1-isopropylindazoles undergo cleavage at the N-N bond to give N-substituted 2-aminobenzophenones.The heterocyclic ring of 1-isopropyl-3-phenylindazole also undergoes cleavage at this bond under the influence of phenyllithium.
