834882-76-7Relevant academic research and scientific papers
Enzymatic resolution of (RS)-β-hydroxy selenides in organic media
Costa, Carlos E.,Clososki, Giuliano C.,Barchesi, Henrique B.,Zanotto, Sandra P.,Nascimento, M. Graca,Comasseto, Joao V.
, p. 3945 - 3954 (2007/10/03)
Kinetic resolutions of a number of β-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS-free Pseudomonas sp. lipase) and CALB (NOVOZYM 435-immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of temperature, solvent, enzyme immobilization and the structure of the substrates on the resolution is presented.
