83490-93-1

Upstream product

• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 141-97-9 ethyl acetoacetate 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-66-3 methoxybenzene 

Downstream Products

• 118209-32-8 1-(2,4-Dichloro-phenyl)-5-(4-methoxy-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 83490-99-7 1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 83491-01-4 5-(4-Methoxy-phenyl)-2-methyl-1-(4-nitro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 94020-32-3 ethyl 2-acetyl-2-(4-methoxybenzoylmethyl)pent-4-enoate 
• 108401-08-7 ethyl 2-acetyl-2-(4-methoxybenzoylmethyl)-5-phenylpent-4-ynoate 
• 108401-10-1 3-(4-methoxyphenyl)-5-(3-phenylprop-2-ynyl)cyclopent-2-en-1-one 
• 108401-06-5 (5E)-3-acetyl-1-(4-methoxyphenyl)-6-phenylhex-5-en-1-one 
• 108401-09-8 3-acetyl-1-(4-methoxyphenyl)-6-phenylhex-5-yn-1-one 
• 108401-25-8 6-(4-methoxyphenyl)-4-endo-phenylbicyclo<3.2.1>oct-6-en-2-one 
• 108401-25-8 6-(4-methoxyphenyl)-4-exo-phenylbicyclo<3.2.1.>oct-6-en-2-one 
• 108401-11-2 3-(4-methoxyphenyl)-5-<(2Z)-3-phenylprop-2-enyl>cyclopent-2-en-1-one 
• 108401-11-2 3-(4-methoxyphenyl)-5-<(2E)-3-phenylprop-2-enyl>cyclopent-2-en-1-one 
• 108401-24-7 6-(4-methoxyphenyl)-4-endo-phenyltricyclo<3.2.1.0^3.6>octan-2-one 
• 108401-24-7 6-(4-methoxyphenyl)-4-exo-phenyltricyclo<3.2.1.0^3.6>octan-2-one 

Relevant academic research and scientific papers

Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction

Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds. However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, we describe a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution. Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers.

Ligand-based design, synthesis and primary in vivo screening of pyrrole derivatives as potential tricyclic anti-inflammatory agents

Twelve new compounds were designed as 5-aryl-1H-pyrrole analogs of celecoxib (CAS 169590-42-5) and were synthesized by Paal-Knorr cyclization in three series according to 1H-substitution: derivatives with salicylic acid, pyrazolone or isonicotinamide resi

Tyrosine phosphatase inhibitors

A compound of the formula (I): wherein X1 and X2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of R1 and R2 is a cycle group having substituent(s) selected from 1) an optionally substituted carboxy-C1-6 alkoxy group and 2) an optionally substituted carboxy-C1-6 aliphatic hydrocarbon group, wherein the cycle group optionally has additional substituent(s), and the other is an optionally substituted cycle group or a hydrogen atom; and R3, R4 and R5 are the same or different and each is a hydrogen atom or a substituent, or R4 may link together with R3 or R5 to form an optionally substituted ring; provided that when R3 is a hydrogen atom, R4 is a hydrogen atom and R5 is methyl, X2—R2 is not 4-cyclohexylphenyl; when R3 is 4-methoxyphenyl, R4 is a hydrogen atom and R5 is methyl, X2—R2 is not 4-methoxyphenyl; and when R1 or R2 is a hydrogen atom, the adjacent X1 or X2 is not a C1-7 alkylene; or a salt thereof exhibits a protein tyrosine phosphatase inhibitory action and is useful as a prophylactic or therapeutic agent for diabetes or the like.