204253-44-1Relevant academic research and scientific papers
Solid-phase synthesis of peptidomimetic oligomers with a phosphodiesterase backbone
Lin, Peishan,Ganesan
, p. 511 - 514 (2007/10/03)
An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.
Synthesis of propane-2,3-diol combinatorial monomers
Acevedo, Oscar L.,Andrews, Robert S.
, p. 3931 - 3934 (2007/10/03)
Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroaryl-propane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.
