834918-68-2Relevant academic research and scientific papers
Aryl nucleoside H-phosphonates. Part 16: Synthesis and anti-HIV-1 activity of di-aryl nucleoside phosphotriesters
Romanowska, Joanna,Szymanska-Michalak, Agnieszka,Boryski, Jerzy,Stawinski, Jacek,Kraszewski, Adam,Loddo, Roberta,Sanna, Giuseppina,Collu, Gabriella,Secci, Barbara,Colla, Paolo La
experimental part, p. 3489 - 3498 (2009/09/30)
Di-aryl nucleoside phosphotriesters have been explored as a new type of pronucleotides for the purpose of anti-HIV-1 therapy and efficient synthetic protocols, based on H-phosphonate chemistry, have been developed for the preparation of this class of comp
New and efficient approach to aryl phosphoramidate derivatives of AZT/d4T as anti-HIV prodrugs
Li, Xueshu,Fu, Hua,Jiang, Yuyang,Zhao, Yufen,Liu, Jinyong
, p. 2600 - 2602 (2007/10/03)
Ester exchange of diaryl phosphite with AZT or d4T produced aryl AZT/d4T H-phosphonate, and the following reaction with amino acid esters in the presence of hexachloroethane and triethylamine yielded membrane-soluble anti-HIV prodrugs aryl phosphoramide d
Aryl H-phosphonates. 14. Synthesis of new nucleotide analogues with phosphonate-phosphate internucleosidic linkage
Szymczak, Marzena,Szymanska, Agnieszka,Stawinski, Jacek,Boryski, Jerzy,Kraszewski, Adam
, p. 3571 - 3573 (2007/10/03)
(Equation presented) Aryl nucleoside H-phosphonates 3 and aryl nucleoside P-acylphosphonates 4, generated in situ from the appropriate H-phosphonate 1 and acylphosphonate monoesters 2, respectively, reacted rapidly in the presence of tertiary amines to pr
