83501-14-8Relevant academic research and scientific papers
Transition metal-free diastereospecific synthesis of (Z)-2-arylidene-2,3-dihydrobenzo[b][1,4]dioxines by reaction of (Z)-1,2-dibromo-3-aryl-2-propenes with catechols
Beifuss, Uwe,Bharatam, Prasad V.,Conrad, Jürgen,Frey, Wolfgang,Rekowski, Szymon P.,Wani, Aabid A.
, (2020/09/18)
A transition metal-free, diastereospecific reaction between substituted (Z)-1,2-dibromo-3-phenyl-2-propenes and substituted catechols using Cs2CO3 as a base at 140 °C for 18 h delivers exclusively substituted (Z)-2-arylidene-2,3-dihy
Competitive, substrate-dependent reductive debromination/dehydrobromination of 1,2-dibromides with triethylamine
McGraw, Kristen M.,Kent, Greggory T.,Gonzalez, Joseph R.,Erden, Ihsan,Wu, Weiming
, p. 1973 - 1975 (2017/04/27)
The interaction of various 1,2-dibromides with NEt3 under various conditions (THF and DMF, respectively) at different temperatures was investigated. Our results from these reactions show that substrate dependent dehydrobrominations compete with reductive debrominations. A comprehensive discussion of these competitive pathways is offered.
Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones
Gong, Xiaoyu,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Zhao, Yufen,Fu, Hua
supporting information; experimental part, p. 3128 - 3131 (2010/09/04)
(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.
