883-62-5

Basic information

• Product Name: 3-METHOXY-2-NAPHTHOIC ACID
• Synonyms: 3-methoxy-2-naphthalenecarboxylicaci;3-Methoxy-naphthalene-2-carboxylic acid;3-Methoxy-2-naphthalenecarboxylic acid;2-Methoxy-3-naphthoic acid;2-Naphthalenecarboxylic acid, 3-methoxy-;2-Naphthoic acid, 3-methoxy-;Einecs 212-932-7;Nsc 36216
• CAS NO: 883-62-5
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• EINECS: 212-932-7
• Product Categories: C11 to C12;Carbonyl Compounds;Carboxylic Acids
• Mol File: 883-62-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 133-136 °C(lit.)
• Boiling Point: 358.8°C at 760 mmHg
• Flash Point: 142.1°C
• Appearance: /
• Density: 1.263±0.06 g/cm3(Predicted)
• Vapor Pressure: 9.02E-06mmHg at 25°C
• Solubility: soluble in Methanol
• PKA: 4.09±0.30(Predicted)
• CAS DataBase Reference: 3-METHOXY-2-NAPHTHOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-2-NAPHTHOIC ACID(883-62-5)
• EPA Substance Registry System: 3-METHOXY-2-NAPHTHOIC ACID(883-62-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 883-62-5(Hazardous Substances Data)

Usage

Uses

3-Methoxy-2-naphthoic acid may be used in the synthesis of N-[p-N,N-dimethylanilino)-3-methoxy-2-naphtho]hydroxamic acid (DAMNHA).

General Description

3-Methoxy-2-naphthoic acid is a naphthoic acid derivative. 3-Methoxy-2-naphthoic acid can be prepared from 3-hydroxy-2-naphthoic acid, via methylation. It undergoes reduction under the following reaction conditions:in the presence of Li and NH4Cl to afford 1,2,3,4-tetrahydro-2-naphthoic acidby using Li, NH4Cl and anhydrous FeCl3 to afford 3-methoxy-1, 2-dihydro-2-naphthoic acidin anhydrous ether, liquid ammonia, lithium wire and anhydrous ethanol to afford 1,2,3,4-tetrahydro-2-naphthoic acid

InChI:InChI=1/C12H10O3/c1-15-11-7-9-5-3-2-4-8(9)6-10(11)12(13)14/h2-7H,1H3,(H,13,14)/p-1

Upstream product

• 109-72-8 n-butyllithium 
• 93-04-9 2-Methoxynaphthalene 
• 390755-15-4 3-methoxy-2-naphthoyloxyl radical 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 74-88-4 methyl iodide 
• 124-38-9 carbon dioxide 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 82261-01-6 Norweberine hydrochloride 
• 58778-69-1 3-methoxy-2-naphthoyl chloride 
• 390755-10-9 1-(3-methoxy-2-naphthoyloxy)-2-pyridone 
• 3401-47-6 1-bromo-2-methoxynaphthalene 
• 77-78-1 dimethyl sulfate 
• 13041-60-6 methyl 3-methoxy-2-naphthoate 

Downstream Products

• 1224567-52-5 N-(4-chloro-2-hydroxyphenyl)-3-methoxy-2-naphthamide 
• 1224567-36-5 5-chloro-2-(3-methoxy-2-naphthamido)phenyl 3-methoxy-2-naphthoate 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 129103-89-5 2-hydroxy-2',3',4'-trimethoxynaphthalophenone 
• 22315-94-2 1,3-dihydroxy-12H-benzo[b]xanthen-12-one 
• 1415045-80-5 N,N-diethyl-3-phenyl-2-naphthamide 
• 228401-15-8 2-(N-(carbobenzyloxy)amino)-3-methoxynaphthalene 
• 50885-12-6 1-amino-3-methoxynaphthalene 
• 5417-63-0 3-Amino-2-naphthol 
• 58698-34-3 N,N'-bis-(3-methoxy-[2]naphthoyl)-hydrazine 
• 58698-35-4 3-methoxy-2-naphthoic hydrazide 
• 92616-44-9 3-methoxy-2-naphthonitrile 
• 67291-63-8 2-amino-3-methoxynaphthalene 

Relevant articles and documents

Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F–H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π–π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

Naphthyl, (substituted) aryl, piperazine base trunk apperception composition

The invention discloses (substituted) naphthyl, (substituted) aryl, piperazinyl amidine compound with new structures and salt of medical acid, a preparation method and a purification method of the compound and the salt of the medical acid, and a medicine composition containing the compound, wherein the compound has double inhibition activities of 5-hydroxytryptamine (5-HT) reuptake and noradrenalin (NE) reuptake, and shows strong depression resistance in animal experiments. The compound can be used for treating tristimania, and can also be used for treating other nervous system diseases related to the 5-HT and the NE.

Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.