883-62-5

Usage

Uses

Used in Chemical Synthesis:
3-Methoxy-2-naphthoic acid is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the formation of different functional groups and derivatives, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Industry:
3-Methoxy-2-naphthoic acid is used as a starting material for the synthesis of N-[p-N,N-dimethylanilino)-3-methoxy-2-naphtho]hydroxamic acid (DAMNHA). DAMNHA is a compound of interest in pharmaceutical research, with potential applications in the development of new drugs and therapeutic agents.

InChI:InChI=1/C12H10O3/c1-15-11-7-9-5-3-2-4-8(9)6-10(11)12(13)14/h2-7H,1H3,(H,13,14)/p-1

Upstream product

• 109-72-8 n-butyllithium 
• 93-04-9 2-Methoxynaphthalene 
• 13041-60-6 methyl 3-methoxy-2-naphthoate 
• 77-78-1 dimethyl sulfate 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 124-38-9 carbon dioxide 
• 3401-47-6 1-bromo-2-methoxynaphthalene 
• 390755-15-4 3-methoxy-2-naphthoyloxyl radical 
• 390755-10-9 1-(3-methoxy-2-naphthoyloxy)-2-pyridone 
• 58778-69-1 3-methoxy-2-naphthoyl chloride 
• 82261-01-6 Norweberine hydrochloride 
• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 883-99-8 3-hydroxy-2-naphthoic acid methyl ester 
• 53440-12-3 1,2,3,4-tetrahydro-2-naphthoic acid 
• 22315-94-2 1,3-dihydroxy-12H-benzo[b]xanthen-12-one 
• 129103-89-5 2-hydroxy-2',3',4'-trimethoxynaphthalophenone 
• 1415045-80-5 N,N-diethyl-3-phenyl-2-naphthamide 
• 1224567-52-5 N-(4-chloro-2-hydroxyphenyl)-3-methoxy-2-naphthamide 
• 1224567-36-5 5-chloro-2-(3-methoxy-2-naphthamido)phenyl 3-methoxy-2-naphthoate 
• 228401-15-8 2-(N-(carbobenzyloxy)amino)-3-methoxynaphthalene 
• 50885-12-6 1-amino-3-methoxynaphthalene 
• 5417-63-0 3-Amino-2-naphthol 
• 58698-34-3 N,N'-bis-(3-methoxy-[2]naphthoyl)-hydrazine 

Relevant academic research and scientific papers

Enantioselective Synthesis of 3,3′-Disubstituted 2-Amino-2′-hydroxy-1,1′-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel CuI/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3′-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F–H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the π–π stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

* One derivative containing nitrogen and its preparation method and application (by machine translation)

The invention discloses a formula (I) of formula (II) containing nitrogen mouth Shan Tong derivative and its preparation method and application, A new synthesis of this invention containing nitrogen mouth Shan Tong derivatives of the salt and its acid salt, increased solubility, active research indicates part of the compound at the same time with treating and/or preventing diabetes and complications from diabetes mellitus the role of the, can further carry out development research as a model for treating and/or preventing diabetes caused by the complications of diabetes medicine. (by machine translation)

Naphthyl, (substituted) aryl, piperazine base trunk apperception composition

The invention discloses (substituted) naphthyl, (substituted) aryl, piperazinyl amidine compound with new structures and salt of medical acid, a preparation method and a purification method of the compound and the salt of the medical acid, and a medicine composition containing the compound, wherein the compound has double inhibition activities of 5-hydroxytryptamine (5-HT) reuptake and noradrenalin (NE) reuptake, and shows strong depression resistance in animal experiments. The compound can be used for treating tristimania, and can also be used for treating other nervous system diseases related to the 5-HT and the NE.

Metalation of 2-heterosubstituted naphthalenes at the 1- or 3- position: Factors that may determine the regiochemistry

Upon metalation and subsequent electrophilic trapping, 2-fluoronaphthalene inevitably gives rise to regioisomeric mixtures in varying proportions, whereas 2-(trifluoromethyl)naphthalene undergoes deprotonation either at the 1- or the 3-position, depending on the choice of the reagent. On the other hand, 2-(trifluo-romethoxy)naphthalene and 2-methoxynaphthalene react exclusively at the 3-position when, respectively, sec-butylhthium and superbasic reagents are employed. Steric repulsion by the peri hydrogen in combination with crowding due to coordination of the lithium atom with the methoxy group disfavors attack at the 1-position. Georg Thieme Verlag Stuttgart.

Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

Solid state S-methylation of thiols and O-methylation of phenols and naphthols with dimethyl sulfate under microwave irradiation

Mild and efficient S-methylation of thiols and o-methylation of phenols and naphthals occurs with dimethyl sulfate (DMS) supported on basic alumina under microwave irradiation in solventless system. Copyright Taylor & Francis Inc.

INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS

This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.

Synthesis and structural analysis of oligo(naphthalene-2,3-diyl)s

Oligo(naphthalene-2,3-diyl)s are synthesized by the palladium-catalyzed cross-coupling reactions of 2-naphthyl-zinc compounds with 2-bromonaphthalene derivatives. An NMR analysis together with an X-ray diffraction study supports the conjecture that the helical secondary structure is a common feature of the assemblies in which naphthalene-like aromatic units are linked together between the β-positions in series.

Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas

This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.

Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.