83521-99-7

Usage

Chemical structure

1,3-Diazaspiro(4.4)nonane-2,4-dithione

Type of compound

Dithione derivative

Structure

Unique spirocyclic structure

Potential applications

a. Organic synthesis
b. Medicinal chemistry

Studied properties

a. Antimicrobial
b. Antiviral
c. Antifungal

Additional activities

a. Antioxidant
b. Anti-inflammatory

Current status

Ongoing research for various properties and potential applications

Therapeutic potential

Promising candidate for the development of new pharmaceuticals

InChI:InChI=1/C7H10N2S2/c10-5-7(3-1-2-4-7)9-6(11)8-5/h1-4H2,(H2,8,9,10,11)

Upstream product

• 75-15-0 carbon disulfide 
• 49830-37-7 1-amino-1-cyanocyclopentane 
• 143-33-9 sodium cyanide 
• 120-92-3 cyclopentanone 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 

Downstream Products

• 98334-44-2 4-thioxo-1,3-diaza-spiro[4.4]nonan-2-one 
• 14109-98-9 cyclopentanespiro-5-(2-thiohydantoin) {cyclopentanespiro-5-(2-thioxoimidazolidin-4-one)} 

Relevant academic research and scientific papers

Synthesis, spectroscopic characterization and ab initio investigation of thioanalogues of spirohydantoins

Dithioanalogues of cycloalkanespiro-5-hydantoins were prepared by reaction of the respective spirohydantoins with Lawesson's reagent or P4S 10. Cycloalkanespiro-5-(2-thiohydantoins) and cycloalkanespiro-5-(4- hydantoins) were also synthesized from cycloalkanespiro-5-(2,4-dithiohydantoins) via different reaction pathways. The structures of the compounds obtained were verified by 1H, 13C NMR and IR spectroscopy. Quantum-chemical calculations at the ab initio level of molecular nonlinear characteristics were performed. Increase of polarizability α and the second hyperpolarizability ? with enlarging the saturated ring was observed in all the structures studied.

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.

1,3-Diaminomethyl-hydantoin additives for lubricating oils

Lubricating oil compositions, comprising as additive, from 0.001 to 10% by weight, based on the weight of the total composition, of a 1- or 3-aminomethyl-hydantoin or a 1,3-diaminomethyl-hydantoin.