83564-57-2

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 83564-52-7 4-(4-Formyl-4,5-dihydro-3H-pyrrol-2-ylsulfanyl)-butyric acid ethyl ester 
• 83564-49-2 5-thioxopyrrolidine-3-carboxylic acid methyl ester 
• 83564-50-5 4-Hydroxymethylpyrrolidin-2-thion 
• 35309-35-4 5-oxopyrrolidine-3-carboxylic acid methyl ester 
• 85492-64-4 4-[4-((E)-5-Benzyloxy-4,4-dimethyl-3-oxo-pent-1-enyl)-4,5-dihydro-3H-pyrrol-2-ylsulfanyl]-butyric acid ethyl ester 
• 83564-51-6 4-(4-Hydroxymethyl-4,5-dihydro-3H-pyrrol-2-ylsulfanyl)-butyric acid ethyl ester 

Relevant academic research and scientific papers

SYNTHESE VON (+/-)-(E)-2-(1-THIA-4-AETOXYCARBONYLBUTYL)-4-(3-HYDROXY-1-OCTENYL)-1Δ-PYRROLIN UND SEINER ANALOGEN

Starting from 4-methoxycarbonylpyrrolidin-2-one (1) the racemic thiolactim ethers (7a-h) can be obtained via S-alkylation of the thiolactam alcohol (3), subsequent oxidation, Horner-Emmons-Wittig reaction and reduction of the enones.