83564-49-2

Upstream product

• 35309-35-4 5-oxopyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 500136-15-2 5-thioxopyrrolidine-1,3-dicarboxylic acid dimethyl ester 
• 83564-58-3 4-[4-((E)-3-Cyclohexyl-3-hydroxy-propenyl)-4,5-dihydro-3H-pyrrol-2-ylsulfanyl]-butyric acid ethyl ester 
• 85492-67-7 4-[4-((E)-3-Cyclohexyl-3-oxo-propenyl)-4,5-dihydro-3H-pyrrol-2-ylsulfanyl]-butyric acid ethyl ester 
• 83564-57-2 4-[4-((E)-5-Benzyloxy-3-hydroxy-4,4-dimethyl-pent-1-enyl)-4,5-dihydro-3H-pyrrol-2-ylsulfanyl]-butyric acid ethyl ester 
• 85492-64-4 4-[4-((E)-5-Benzyloxy-4,4-dimethyl-3-oxo-pent-1-enyl)-4,5-dihydro-3H-pyrrol-2-ylsulfanyl]-butyric acid ethyl ester 
• 500135-98-8 1-tert-butyl 3-methyl 5-thioxopyrrolidine-1,3-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of pyrrolo[2,3-d][1,2,3]thiadiazole-6-carboxylates via the Hurd-Mori reaction. Investigating the effect of the N-protecting group on the cyclization

A route to methyl pyrrolo[2,3-d][1,2,3]thiadiazole-6-carboxylates as potential plant activators and inducers of systemic acquired resistance (SAR) is reported. A synthetic strategy based on cyclization of the thiadiazole ring system utilizing thionyl chloride via the Hurd-Mori protocol as key step was developed. Success of the ring closure reaction turned out to be highly dependent on the nature of the N-protecting group of the pyrrolidine precursor. While electron donors such as alkyl gave only poor conversion to the required 1,2,3-thiadiazoles, an electron withdrawing substituent such as methyl carbamate gave superior yields.

Δ1 -Pyrroline thiolactim ethers and a process for their preparation

The present invention relates to Δ1 -pyrroline thiolactim ethers of the general formula I STR1 which have a more specific action and/or a longer-lasting action than PGI2, and to a process for their preparation. The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.

SYNTHESE VON (+/-)-(E)-2-(1-THIA-4-AETOXYCARBONYLBUTYL)-4-(3-HYDROXY-1-OCTENYL)-1Δ-PYRROLIN UND SEINER ANALOGEN

Starting from 4-methoxycarbonylpyrrolidin-2-one (1) the racemic thiolactim ethers (7a-h) can be obtained via S-alkylation of the thiolactam alcohol (3), subsequent oxidation, Horner-Emmons-Wittig reaction and reduction of the enones.