83566-27-2Relevant academic research and scientific papers
Regioselectivity in preparation of unsymmetrically substituted 3-aminoquinoxalin-2(1H)-ones
Csikos, Eva,Goenczi, Csaba,Podanyi, Benjamin,Toth, Gabor,Hermecz, Istvan
, p. 1789 - 1793 (2007/10/03)
Regioisomer formation has to be considered in the preparation of quinoxalines having different substituents at the 2- and 3-position. Oxalomonoimidic acid dimethyl ester or oxalompnoimidic acid diethyl ester, chloro(methyl- , imino)acetic acid ethyl ester, chloro[(Z)-hydroxyimino]acetic acid ethyl ester and (Z)-2-[(E)-hydroxyimino]acetohydroximoyl chloride were applied to the synthesis of 3-aminoquinoxalin-2(1H)-one derivatives, and the isomer ratio was investigated concerning the reactivity of the ring-closure reagent. The structures of reaction products . were identified using 1H, 13C and 15N NMR techniques. A direct synthesis of quinoxaline-2,3(1H,4H)-dione 3-oximes is described.
Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones
McKillop, Alexander,Chattopadhyay, Shital K.,Henderson, Alan,Avendano, Carmen
, p. 301 - 304 (2007/10/03)
Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.
HETEROCYCLIC SYNTHESIS USING ETHYL CARBOETHOXYFORMIMIDATE
McKillop, Alexander,Henderson, Alan,Ray, Partha S.,Avendano, Carmen,Molinero, Encarnacion G.
, p. 3357 - 3360 (2007/10/02)
Ethyl carboethoxyformimidate is shown to be a versatile reagent for the synthesis of a variety of mono- and bicyclic heterocyclic systems.
