816-27-3

Basic information

• Product Name: ETHOXY-IMINO-ACETIC ACID ETHYL ESTER
• Synonyms: (1-Ethoxyformimidoyl)formic acid ethyl ester;Ethyl 1-carbethoxyformimidate;ETHOXY-IMINO-ACETIC ACID ETHYL ESTER;2-Ethoxy-2-iminoacetic acid ethyl ester;Ethyl 2-ethoxy-2-iminoacetate;Ethyl carboethoxyformidimate;Ethyl ethoxycarbonylformimidate;Ethyl ethoxyiminoacetate
• CAS NO: 816-27-3
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Mol File: 816-27-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 151℃
• Flash Point: 45℃
• Appearance: /
• Density: 1.08
• Vapor Pressure: 3.729mmHg at 25°C
• Refractive Index: n20/D1.426
• Storage Temp.: ?20°C
• PKA: 3.21±0.70(Predicted)
• CAS DataBase Reference: ETHOXY-IMINO-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ETHOXY-IMINO-ACETIC ACID ETHYL ESTER(816-27-3)
• EPA Substance Registry System: ETHOXY-IMINO-ACETIC ACID ETHYL ESTER(816-27-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 816-27-3(Hazardous Substances Data)

Usage

General Description

ETHOXY-IMINO-ACETIC ACID ETHYL ESTER, also known as ethyl 2-ethoxyiminoacetate, is a chemical compound with the molecular formula C6H11NO3. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. ETHOXY-IMINO-ACETIC ACID ETHYL ESTER is also used as a solvent and as a reagent in organic synthesis. It is a clear, colorless liquid with a slightly fruity odor, and it is flammable. ETHOXY-IMINO-ACETIC ACID ETHYL ESTER should be handled and stored with caution, as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C6H11NO3/c1-3-9-5(7)6(8)10-4-2/h7H,3-4H2,1-2H3

Upstream product

• 75-03-6 ethyl iodide 
• 623-49-4 ethyl cyanoformate 
• 64-17-5 ethanol 

Downstream Products

• 143-33-9 sodium cyanide 
• 105-58-8 Diethyl carbonate 
• 736090-04-3 ethyl 2-amino-2-iminoacetate 
• 83566-31-8 6-Amino-1H,8H-pteridine-2,4,7-trione 
• 83566-27-2 3-Amino-7-methylquinoxalin-2(1H)-one 
• 83566-26-1 3-amino-6-methylquinoxalin-2(1H)-one 
• 1871-89-2 N,N'-bis-(2-hydroxyethyl)oxamide 
• 3299-61-4 N,N'-Di-p-tolyloxalamide 
• 80945-63-7 methyl 2-oxo-2-(p-tolylamino)acetate 

Relevant articles and documents

HETEROCYCLIC AMIDES AS KINASE INHIBITORS FOR USE IN THE TREATMENT CANCER

Disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg. Also disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg, and administering to the human a PD1 antagonist thereof at a dose of about 200 mg.

INHIBITORS OF PI3 KINASE

The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.

Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones

Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.