816-27-3

Usage

Uses

Used in Pharmaceutical Industry:
ETHOXY-IMINO-ACETIC ACID ETHYL ESTER is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, ETHOXY-IMINO-ACETIC ACID ETHYL ESTER is employed as an intermediate in the production of agrochemicals, aiding in the creation of substances that protect crops and enhance agricultural productivity.
Used as a Solvent:
ETHOXY-IMINO-ACETIC ACID ETHYL ESTER is utilized as a solvent in various chemical processes, providing a medium for reactions to occur and facilitating the dissolution of other substances.
Used as a Reagent in Organic Synthesis:
ETHOXY-IMINO-ACETIC ACID ETHYL ESTER is also used as a reagent in organic synthesis, playing a crucial role in the formation of new chemical entities and contributing to the advancement of organic chemistry.

InChI:InChI=1/C6H11NO3/c1-3-9-5(7)6(8)10-4-2/h7H,3-4H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 623-49-4 ethyl cyanoformate 
• 75-03-6 ethyl iodide 

Downstream Products

• 143-33-9 sodium cyanide 
• 105-58-8 Diethyl carbonate 
• 898-22-6 triethyl 1,3,5-triazine-2,4,6-tricarboxylate 
• 2211-33-8 N-phenylparabanic acid 
• 107972-62-3 ethyl s-triazolo<1,5-a>pyridine-2-formimidate 
• 62135-58-4 ethyl s-triazolo<1,5-a>pyridine-2-carboxylate 
• 1871-89-2 N,N'-bis-(2-hydroxyethyl)oxamide 
• 83566-27-2 3-Amino-7-methylquinoxalin-2(1H)-one 
• 83566-26-1 3-amino-6-methylquinoxalin-2(1H)-one 
• 35015-91-9 3-amino-2(1H)-quinoxalinone 
• 83566-34-1 3-amino-1,4-benzoxazin-2-one 
• 29198-43-4 benzothiazole-2-amide 
• 32137-76-1 benzothiazole-2-carboxylic acid ethyl ester 
• 73185-67-8 ethyl 5-phenylamino-1,3,4-thiadiazole-2-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC AMIDES AS KINASE INHIBITORS FOR USE IN THE TREATMENT CANCER

Disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg. Also disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg, and administering to the human a PD1 antagonist thereof at a dose of about 200 mg.

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed is a combination of a RIP1 kinase inhibitor compound and at least one other therapeutically active agent for use in the treatment of a RIP1 kinase mediated disease or disorder; particularly disclosed is a combination of a RIP1 kinase inhibitor compound and at least one other therapeutically active agent, wherein the at least one other therapeutically active agent is an immuno-modulator, for use in the treatment of cancer.

INHIBITORS OF PI3 KINASE

The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.

HETEREOARYL NITRILE DERIVATIVES

The invention provides compounds of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical con

Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones

Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.

Synthesis of 4-Alkoxy-1,3-oxazol-5(2H)-ones, Precursors of 1-Alkoxy-Substituted Nitrile Ylides

4-Alkoxy-1,3-oxazol-5(2H)-ones of type 4 and 7 were synthesized by two different methods: oxidation of the 4-(phenylthio)-1,3-oxazol-5(2H)-one 2a with m-chloroperbenzoic acid in the presence of an alcohol gave the corresponding 4-alkoxy derivatives 4, presumably via nucleophilic substitution of an intermediate sulfoxide (Scheme 2).The second approach is the BF3-catalyzed condensation of imino-acetates of type 6 and ketones (Scheme 3).The yields of this more straightforward method were modest due to the competitive formation of 1,3,5-triazine tricarboxylate 8.At 155 deg C, 1,3-oxazol-5(2H)-one 7b underwent decarboxylation leading to an alkoxy-substituted nitrile ylide which was trapped in a 1,3-dipolar cycloaddition by trifluoro-acetophenone to give the dihydro-oxazoles cis- and trans-9 (Scheme 4).In the absence of a dipolarophile, 1,5-dipolar cyclization of the intermediate nitrile ylide yielded isoindole derivatives 10 (Schemes 4 and 5).

Cephem and cepham compounds

This invention relates to new cephem and cepham compounds of high antimicrobial activity of the formula: STR1 wherein R1 is amino or a protected amino, R2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower)alkenyl, or S or O containing 5-membered heterocyclic group substituted with oxo group(s), R3 is hydrogen or lower alkyl, R4 is hydrogen, acyloxy(lower)alkyl; acylthio(lower) alkyl; pyridinium(lower)alkyl which may be substituted with suitable substituent(s); a heterocyclicthio(lower)alkyl which may be substituted with suitable substituent(s); lower alkyl;l halogen; hydroxy; thiazolium(lower)alkyl which may be substituted with suitable substituent(s); or lower alkoxy; R5 is carboxy or a protected carboxy, wherein R5 is COO- when R4 is pyridinium(lower)alkyl which may be substituted with suitable substituent(s) or thiazolium(lower)alkyl which may be substituted with suitable substituent(s), and the heavy solid line means single or double bond; and pharmaceutically acceptable salt thereof.

Cephem and cepham compounds

This invention relates to novel 7-thiadiazol-oxyimino-3-cephem and cepham 4-carboxylic acid compounds of high antimicrobial activity.

Cephem and cepham compounds

7-Substituted-3-cephem and cepham-4-carboxylic acids represented by the following formula (I): STR1 wherein R1 is amino or a protected amino, R2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower)alkenyl, or S or O containing 5-membered heterocyclic group substituted with oxo group(s), R3 is hydrogen or lower alkyl, R4 is hydrogen; acyloxy(lower)alkyl); acylthio(lower)alkyl; pyridinium(lower)alkyl which may be substituted with suitable substituent(s); a heterocyclicthio(lower)alkyl which may be substituted with suitable substituent(s); lower alkyl; halogen; or hydroxy; and, R5 is carboxy or a protected carboxy, wherein R5 is COO- when R4 is pyridinium(lower)alkyl which may be substituted with suitable substituent(s), and the heavy solid line means single or double bond, are useful as antibiotics.