83575-46-6 Usage
Uses
Used in Biochemical Research:
N-(Benzyloxycarbonyl)glycyl-L-prolyl-N5-carbamoyl-N-(4-nitrophenyl)-L-ornithinamide is used as a research tool for studying enzyme inhibitors, protein structures, and drug development due to its complex structure and properties that facilitate the understanding of molecular interactions.
Used in Pharmaceutical Development:
In the pharmaceutical industry, N-(Benzyloxycarbonyl)glycyl-L-prolyl-N5-carbamoyl-N-(4-nitrophenyl)-L-ornithinamide is used as a substrate or inhibitor in the study of peptidase and protease activities. Its role in these studies aids in the development of pharmaceuticals that target these enzymes, potentially leading to new therapeutic agents for various diseases and conditions.
Used in Enzyme Activity Studies:
N-(Benzyloxycarbonyl)glycyl-L-prolyl-N5-carbamoyl-N-(4-nitrophenyl)-L-ornithinamide is utilized as a substrate in the study of enzyme activity, particularly focusing on peptidases and proteases. This application is crucial for gaining insights into the mechanisms of these enzymes and their roles in biological processes, which can be instrumental in the advancement of medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 83575-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,7 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83575-46:
(7*8)+(6*3)+(5*5)+(4*7)+(3*5)+(2*4)+(1*6)=156
156 % 10 = 6
So 83575-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C27H33N7O8/c28-26(38)29-14-4-8-21(24(36)31-19-10-12-20(13-11-19)34(40)41)32-25(37)22-9-5-15-33(22)23(35)16-30-27(39)42-17-18-6-2-1-3-7-18/h1-3,6-7,10-13,21-22H,4-5,8-9,14-17H2,(H,30,39)(H,31,36)(H,32,37)(H3,28,29,38)/t21-,22-/m0/s1
83575-46-6Relevant academic research and scientific papers
PREPARATION AND PROPERTIES OF SOME CITRULLINE p-NITROANILIDE DERIVARIVES FOR POSSIBLE USE AS PROTEASE SUBSTRATES
Gray, C. J.,Boukouvalas, J.,Barker, S. A.
, p. 1465 - 1470 (2007/10/02)
A number of citrulline p-nitroanilides have been synthesised as potential substrates for proteolytic enzymes.Nα-Benzyloxycarbonyl-L-citrulline p-nitroanilide, a key starting material, was prepared by the phosphoazo method.During this reaction, depending on the conditions, lactam formation and decarbamoylation took place.It is probable that decarbamoylation took place subsequent to the lactamisation step.The derivatives prepared included some protected tripeptide nitroanilides, benzyloxycarbonylglycyl-L-prolyl-L-citrulline p-nitroanilide, benzyloxycarbonyl-D-phenylalanyl-L-prolyl-L-citrulline p- nitroanilide, benzyloxycarbonylglycyl-L-phenylalanyl-L-citrulline p-nitroanilide, methyloxycarbonylglycyl-L-phenylalanyl-L-citrulline p-nitroanilide and a protected tetrapeptide, benzyloxycarbonylglycyl glycyl-L-phenylalanyl-L-citrulline p-nitroanilide.Preliminary results have indicated that citrulline p-nitroanilides are far more susceptible to hydrolysis by plant thiol enzymes such as papain, ficin and bromelain than by mammalian proteases.
