83576-58-3Relevant academic research and scientific papers
Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation
Pérez, Juana M.,Postolache, Roxana,Casti?eira Reis, Marta,Sinnema, Esther G.,Vargová, Denisa,De Vries, Folkert,Otten, Edwin,Ge, Luo,Harutyunyan, Syuzanna R.
supporting information, p. 20071 - 20076 (2021/12/03)
Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.
Nickel-catalyzed regioselective hydrocyanation of terminal alkynes by assistance of a tosyl group
Arai, Shigeru,Nakazawa, Koichi,Yang, Xiao-fei,Nishida, Atsushi
, p. 2482 - 2485 (2019/03/26)
Nickel-catalyzed regioselective hydrocyanation of terminal alkynes is described. A tosylamide functionality at the propargyl position was the most suitable group for controlling the regiochemistry for C–CN bond formation as well as rate enhancement. A gram-scale synthesis was achieved by minimizing the catalyst loading to 2 mol%. The major HCN adduct could be transformed to the corresponding indoline through construction of a benzylic quaternary carbon under iron catalysis.
PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES
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Page/Page column 13; 37; 38, (2018/12/13)
The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E- configured alkenyl nitriles and the catalyst used in the present process.
Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes
Ye, Fei,Chen, Junting,Ritter, Tobias
supporting information, p. 7184 - 7187 (2017/06/05)
We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.
THIOL ESTERS IN ORGANIC SYNTHESIS. XI. A FACILE APPROACH TO β-HYDROXYPROPIONITRILES AND ACRYLONITRILES. CYANOTHIOLACETATE AS MASKED β-HYDROXYPROPIONITRILE CARBANION
Liu, Hsing-Jang,Wynn, Hla
, p. 3151 - 3154 (2007/10/02)
The preparation of β-hydroxypropionitriles and acrylonitriles is facilitated by the use of cyanothiolacetate as a formal equivalent of β-hydroxypropionitrile carbanion.
