83585-61-9 Usage
Uses
Used in Chemical Synthesis:
2-(AMINOMETHYL)-18-CROWN-6 is used as a precursor for the preparation of various chemical compounds, such as:
AM-18-C-6 bonded Merrifield peptide resin for studying the absorption and isotopic effect of magnesium.
Schiff base of gossypol with aminomethyl crown ether for complexation of monovalent cations.
Crown tagged triarylphosphine by reacting with triphenylphosphine carboxylic acid, which is used in Mitsunobu and Heck reactions for the removal of phosphine-derived by-products.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 2-(AMINOMETHYL)-18-CROWN-6 is used as a component in the development of drug delivery systems, such as:
1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (bola A-16), which serves as a vesicular carrier in drug delivery systems, enhancing the efficiency and targeting of therapeutic agents.
These applications highlight the versatility and potential of 2-(AMINOMETHYL)-18-CROWN-6 in various fields, including chemical synthesis and drug delivery, making it a valuable compound for research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 83585-61-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,8 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 83585-61:
(7*8)+(6*3)+(5*5)+(4*8)+(3*5)+(2*6)+(1*1)=159
159 % 10 = 9
So 83585-61-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H27NO6/c14-11-13-12-19-8-7-17-4-3-15-1-2-16-5-6-18-9-10-20-13/h13H,1-12,14H2
83585-61-9Relevant academic research and scientific papers
SYNTHESIS OF CROWN ETHERS BONDED TO A POLYSTYRENE MATRIX THROUGH AN AMIDO LINKAGE AND THEIR USE AS PHASE-TRANSFER CATALYSTS
Anelli, Pier Lucio,Montanari, Fernando,Pollak, Vladimir,Quici, Silvio
, p. 127 - 132 (2007/10/02)
Condensation of amino-functionalized crown ethers with microporous polystyrene bearing carboxyl groups afforded catalysts 15-18, in which the macrocyclic polyether is linked to the matrix through an amino bond.These catalysts are efficient anion activators in aliphatic nucleophilic substitutions under phase-transfer conditions.
Synthesis of Aminomethyl Crown Ethers
Maeda, Hirokazu,Kikui, Takashi,Nakatsuji, Yohji,Okahara, Mitsuo
, p. 5167 - 5171 (2007/10/02)
Various N-substituted or unsubstituted aminomethyl crown ethers, which possess a reactive amino group, were prepared in good yields by the reaction between 3-amino-1,2-propanediols or aminomethyl oligoethylene glycols and oligoethylene glycol ditosylates or dichlorides.The scope of the reaction was investigated and the complexing ability of these new crown ether derivatives with sodium and potassium ions in methanol was measured by potentiometric titration.
