835873-57-9Relevant academic research and scientific papers
Stereoselective enol tosylation: Preparation of trisubstituted α,β-unsaturated esters
Baxter, Jenny M.,Steinhuebel, Dietrich,Palucki, Michael,Davies, Ian W.
, p. 215 - 218 (2005)
(Chemical Equation Presented) The stereoselective preparation of (E)- or (Z)-trisubstituted α,β-unsaturated esters in three steps from N-protected glycine is presented. The key step in the synthesis is the highly selective enol tosylation of γ-amino β-keto esters. The enol tosylates are stable, crystalline compounds that undergo smooth and effective Suzuki-Miyaura coupling reaction with a variety of aryl boronic acids.
