835922-85-5Relevant academic research and scientific papers
Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors
Rong, Frank,Chow, Suetying,Yan, Shunqi,Larson, Gary,Hong, Zhi,Wu, Jim
, p. 1663 - 1666 (2008/02/13)
From chemical compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a substituted quinoxaline hit with an IC50 of 5.5 μM. A series of substituted quinoxaline amide derivatives were synthesized
