836-78-2

Usage

Type of compound

Phenolic compound

Contains

Two trifluoromethyl groups and a hydroxyl group

Usage

Building block in the synthesis of pharmaceuticals, agrochemicals, and materials

Studied for

Antioxidant and antibacterial properties

Potential applications

Food preservation and medical treatment

Known for

Strong and persistent odor (precautions should be taken when handling in its pure form)

Upstream product

• 684-16-2 Hexafluoroacetone 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 
• 555-24-8 lithium phenolate 

Downstream Products

• 400713-17-9 2-[1-(2-benzyloxy-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethoxy]-4,4-bis-trifluoromethyl-4H-benzo[1,3,2]dioxaphosphinine 2-oxide 
• 400713-14-6 1,1,1,3,3,3-hexafluoro-2-[2-(2-oxo-4,4-bis-trifluoromethyl-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxy)-phenyl]-propan-2-ol 

Relevant academic research and scientific papers

New synthesis of polyfluorodiols: Nine new derivatives of HOC(2-OH-C6H4)(CF3)2

Nine new polyfluorodiols, HOC(2-OH-3-C6H3F)(CF3)2, HOC(2-OH-5-C6H3F)(CF3)2, HOC(2-OH-3,5-C6H2F2)(CF3) 2, HOC(2-O

Fluorine-containing compound of fluorine-containing polymerizable monomer and its manufacturing method

PROBLEM TO BE SOLVED: To provide a method for producing a fluorine-containing polymerizable monomer, with which a fluorine-containing compound with a hydroxy fluoroalkyl group bonded to the para position thereof is obtained with high selectivity by making phenols and a fluorine-containing ketone react with each other. SOLUTION: A fluorine-containing compound of general formula (3) is obtained by making a compound of general formula (1) and a fluorine-containing ketone of general formula (2) react with each other in the presence of a fluorine-containing acid catalyst (in formulas, R1-R3respectively and independently represent a hydrogen atom, a straight chain, branched or cyclic alkyl group, an alkenyl group, and so on, and optionally have a fluorine or oxygen atom, R2and R3are optionally bonded to each other and either of them has a fluorine atom, X is an integer of 0-2, and Y is an integer of 0-8). COPYRIGHT: (C)2013,JPOandINPIT

Lithium phosphonate umpolung catalysts: Do fluoro substituents increase the catalytic activity?

Fluorinated and nonfluorinated phosphonates are employed as precatalysts in lithium phosphonate catalyzed cross benzoin couplings. Surprisingly, a decreased catalytic activity for the fluorinated precatalysts compared to the nonfluorinated systems is observed. Furthermore, the ring size of six, seven and nine membered ring catalysts appears not to be crucial for their catalytic activity.

Preparation of fluorinated 1,3-benzodiozanes

The invention relates to novel fluorinated achiral 1,3-benzodioxanes of the general formula (I-a) and (I-b) and to the preparation thereof.