83600-41-3Relevant academic research and scientific papers
Formal Total Synthesis of (+/-)-Pseudomonic Acids from Dihydropyran
Jackson, Richard F. W.,Raphael, Ralf A.,Stibbard, John H. A,Tidbury, Raymond C.
, p. 2159 - 2164 (2007/10/02)
A new, convenient, and stereoselective route to a central intermediate in pseudomonic acid synthesis via the cis-fused γ-lactone, 2,7-dioxabicyclonon-4-en-8-one (3), is described.The required relative stereochemistry of the 2- and 5-side chains is established by a palladium(0)-mediated allylic substitution of the γ-lactone (3) by di-t-butylsodiomalonate.
