83610-72-4

Upstream product

• 83610-44-0 benzyl (2S)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanoyl]pyrrolidine-2-carboxylate 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 125814-33-7 N-(tert-butoxycarbonyl)-L-leucine N-carboxyanhydride 
• 89545-43-7 H-Leu-Pro-OBzl hydrochloride 
• 145929-76-6 Boc-Ile-NCA 

Relevant academic research and scientific papers

Environmentally benign peptide synthesis using liquid-assisted ball-milling: Application to the synthesis of Leu-enkephalin

This paper describes an original methodology for peptide bond synthesis avoiding toxic solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N-carboxyanhydrides (Boc-AA-NCA) or Boc-protected α-amino acid N-hydroxysuccin