83623-93-2

Usage

Uses

Used in Pharmaceutical Industry:
(2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER is used as a building block for the synthesis of pharmaceuticals due to its unique chemical structure and potential applications in the development of new drugs.
Used in Organic Chemistry Research:
In the field of organic chemistry, (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER serves as a valuable tool for studying the properties and behavior of similar compounds, contributing to the advancement of knowledge in organic chemistry.

Upstream product

• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 
• 74-88-4 methyl iodide 

Downstream Products

• 1433946-60-1 N-{5-chloro-4'-[2-((2S,4S)-4-methoxy-pyrrolidin-2-yl)-1H-imidazol-4-yl]-2-trifluoromethoxy-biphenyl-4-yl}-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide 
• 871979-42-9 3-[3-((4S)-methoxy-(2S)-pyrrolidinyl)-5-isoxazol]propionic acid benzyl ester hydrochloride 
• 1433280-29-5 (R)-4-[5-(5-chloro-4'-{2-[(2S,4S)-4-methoxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1433280-27-3 [(S)-1-((2S,4S)-4-methoxy-2-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester 
• 1373164-86-3 (2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1373165-22-0 ((S)-1-{(2S,4S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methoxy-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester 
• 1283142-89-1 2-((2S,4S)-4-methoxy-1-(4-(o-tolyloxy)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt 
• 1283146-42-8 2-((2R,4S)-4-methoxy-1-(4-(o-tolyloxy)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1283146-41-7 ((2S,4S)-4-methoxy-1-(4-(o-tolyloxy)phenyl)pyrrolidin-2-yl)methanol 

Relevant academic research and scientific papers

BENZIMIDAZOLE-PROLINE DERIVATIVES

The present invention relates to compounds of the formula (I) wherein Ar1, R1, R2, R3, R4a, R4b and (R5)n are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of Formula (I) and (II) wherein R1, R2, R3, R6, A and A' are defined herein. The compounds are useful as inhibitors of the function of NS5A protein encoded by HCV for the treatment of hepatitis C viral infection.

Bradykinin type peptides

The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and other additional substituted analogs of bradykinin converts bradykinin agonists into bradykinin antagonists. The invention further includes additional modifications at other positions within the novel 7- and 8-position modified bradykinin antagonists, which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected as by insect bites.