83623-93-2

Basic information

• Product Name: (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
• Synonyms: (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;CIS-1-N-BOC-4-METHOXY-L-PROLINE;(2S,4S)-1-(tert-Butoxycarbonyl)-4-Methoxypyrrolidine-2-carboxylic acid;(2S,4S)-4-Methoxy-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid;(4S)-1-Boc-4-methoxy-L-proline;-4-methoxypyrrolidine-2-carboxylic acid
• CAS NO: 83623-93-2
• Molecular Formula: C₁₁H₁₉NO₅
• Molecular Weight: 245.28
• Mol File: 83623-93-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 362.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.75±0.40(Predicted)
• CAS DataBase Reference: (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(83623-93-2)
• EPA Substance Registry System: (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER(83623-93-2)

Safety Data

• Hazardous Substances Data: 83623-93-2(Hazardous Substances Data)

Usage

General Description

"(2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER" is a chemical compound with the molecular formula C13H21NO5. It is a tert-butyl ester derivative of (2S,4S)-4-methoxy-pyrrolidine-1,2-dicarboxylic acid, which is a naturally occurring amino acid. (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER is often used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the development of new drugs and research in the field of organic chemistry. Additionally, its unique chemical structure makes it a valuable tool for studying the properties and behavior of similar compounds.

Upstream product

• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 
• 74-88-4 methyl iodide 

Downstream Products

• 871979-42-9 3-[3-((4S)-methoxy-(2S)-pyrrolidinyl)-5-isoxazol]propionic acid benzyl ester hydrochloride 
• 1445597-10-3 methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(2-((1R,2R)-2-((R)-3-methylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445590-85-1 (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445590-73-7 methyl ((S)-3-methyl-1-oxo-1-((2S,3aS,6aS)-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)butan-2-yl)carbamate 
• 1445591-86-5 methyl ((S)-1-((2S,3aS,6aS)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1 (2H)-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1433280-27-3 methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1373165-22-0 methyl ((S)-1-((2S,4S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxypyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1433946-58-7 C₁₄H₁₆BrN₃O 
• 1373164-86-3 (2S,4S)-2-[5-(4-bromo-phenyl)-1H-imidazol-2-yl]-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1445589-60-5 methyl ((2S)-1-((3aS,6aS)-2-(5-(4-(2-((1S,2S)-2-carbamoylcyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)hexahydrocyclopenta[b]pyrrol-1(2H)-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1433280-29-5 (R)-4-[5-(5-chloro-4'-{2-[(2S,4S)-4-methoxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1433280-27-3 [(S)-1-((2S,4S)-4-methoxy-2-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester 

Relevant articles and documents

BENZIMIDAZOLE-PROLINE DERIVATIVES

The present invention relates to compounds of the formula (I) wherein Ar1, R1, R2, R3, R4a, R4b and (R5)n are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

Bradykinin type peptides

The substitution of the L-Pro at the 7-position with D-Phe or D-Tic and substitution of the L-Phe at the 8-position with hydroxyproline ethers and thioethers of the peptide hormone bradykinin and other additional substituted analogs of bradykinin converts bradykinin agonists into bradykinin antagonists. The invention further includes additional modifications at other positions within the novel 7- and 8-position modified bradykinin antagonists, which increase enzyme resistance, antagonist potency, and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected as by insect bites.