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Usage

Uses

Used in Personal Care Products:
N-Methyl 1,1-dioxo-isothiazolidine is used as a preservative in personal care products for its effectiveness in inhibiting the growth of microorganisms, which helps maintain product integrity and safety over time.
Used in Household Products:
In household products, N-Methyl 1,1-dioxo-isothiazolidine is used as a preservative to prevent microbial contamination, ensuring the cleanliness and longevity of items such as cleaning agents and detergents.
However, due to the potential for skin irritation and allergic reactions, it is crucial for consumers to be aware of MIT's presence in products and consider alternatives if they experience adverse reactions. This has led to a growing interest in safer preservative options and the development of alternative formulations that can maintain product quality without compromising consumer health.

Upstream product

• 90666-21-0 2-[methyl(methylsulfonyl)amino]ethyl methanesulfonate 
• 83635-06-7 3-chloro-propane-1-sulfonic acid methylamide 
• 74-89-5 methylamine 
• 98572-09-9 2-methyl isothiazoline 

Downstream Products

• 1222186-24-4 2-methyl-N-[1-(2-methyl-1,1-dioxido-5(R)-isothiazolidinyl)cyclohexyl]-2-propane-(S)-sulfinamide 
• 223579-24-6 (3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-(2-methyl-1,1-dioxo-1λ⁶-isothiazolidin-5-yl)-methanol 

Relevant academic research and scientific papers

A new synthesis of sultams from amino alcohols

The base-mediated cyclization of N,O-dimesylate derivatives of cyclic and acyclic amino alcohols provides a simple access to five- and six-member sultams: isothiazolidine-1,1-dioxides and thiazinane-1,1-dioxides respectively.

Novel antiarthritic agents with 1,2-isothiazolidine-1-,1-dioxide (γ- sultam) skeleton: Cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase

Various 1,2-isothiazolidine-1,1-dioxide (γ-sultam) derivatives containing an antioxidant moiety, 2,6-di-tert-butylphenol substituent, were prepared. Some compounds, which have a lower alkyl group at the 2-position of the γ-sultam skeleton, showed potent i

SYNTHESIS OF N-ALKYLISOTHIAZOLIDINES

N-Alkylisothiazolidines were prepared by -sigmatropic rearrangement of allyl 3-alkylaminopropyl sulfoxides to the sulfenates, followed by intramolecular thiophilic substitution of N-alkylamino moieties.