83638-45-3

Basic information

• Product Name: Benzene, 1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethyl]-
• CAS NO: 83638-45-3
• Molecular Formula: C17H20O3
• Molecular Weight: 272.344
• Mol File: 83638-45-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethyl]-(83638-45-3)
• EPA Substance Registry System: Benzene, 1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethyl]-(83638-45-3)

Safety Data

• Hazardous Substances Data: 83638-45-3(Hazardous Substances Data)

Upstream product

• 22255-22-7 3,5,4'-trimethoxystilbene 
• 134029-62-2 (E)-3,4,4',5-tetramethoxystilbene 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 623-12-1 4-chloromethoxybenzene 
• 153139-20-9 (+/-)-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanol 
• 10272-07-8 3.5-dimethoxyaniline 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 58436-28-5 dihydroresveratrol 
• 74-88-4 methyl iodide 
• 596096-06-9 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1-methoxyethane 
• 917471-56-8 (E)-2,4-dimethoxy-1-(4'-methoxystyryl)benzene 

Downstream Products

• 58436-28-5 dihydroresveratrol 

Relevant articles and documents

Prevention of Marine Biofouling Using the Natural Allelopathic Compound Batatasin-III and Synthetic Analogues

The current study reports the first comprehensive evaluation of a class of allelopathic terrestrial natural products as antifoulants in a marine setting. To investigate the antifouling potential of the natural dihydrostilbene scaffold, a library of 22 syn

Complete NMR data of methoxylated cis- and trans-stilbenes as well as 1,2-diphenylethanes

Resveratrol is a polyphenol isolated from many natural sources including grapes, mulberries, eucalyptus, spruce, lilies, and peanuts. The hydroxyl groups in polyphenols can be substituted with various functional groups, allowing production of multiple derivatives. NMR spectroscopy is used to identify new derivatives. Since the complete NMR data of the known derivatives can be useful for identification of the newly isolated derivatives, here, we report the synthesis of 14 methoxylated stilbenes and four 1,2-diphenylethanes and their NMR data.

Chemo-enzymatic synthesis and cell-growth inhibition activity of resveratrol analogues

The stilbenoid resveratrol (1) was subjected to regioselective acetylation catalysed by Candida antarctica lipase (CAL) to obtain 4′- acetylresveratrol (2). CAL biocatalysed regioselective alcoholysis of 3,5,4′-triacetylresveratrol (3), 3,5,4′-tributanoylresveratrol (6), and 3, 4, 5′-trioctanoylresveratrol (9) afforded derivatives 4, 5, 7, 8, 10, and 11. Further resveratrol analogues (12-18) were obtained through methylation and hydrogenation reactions, whereas the 3,4,4′- trimethoxystilbene (19) was obtained by complete synthesis. Resveratrol and its lipophylic analogues were subjected to cell-growth inhibition bioassays towards DU-145 human prostate cancer cells. Compounds 2-19 showed cell-growth inhibition activity comparable to or higher than resveratrol (GI50 = 24.09 μM), displaying low or very low toxicity against non-tumorigenic human fibroblast cells. Comparison of the trimethoxy stilbenes 12 (GI50 = 2.92 μM) and 19 (GI50 = 25.39 μM) indicates that the position of the substituents is important for the activity. The marked activity of methyl ethers 12, 13, and 18 in comparison with that of the corresponding esters suggests that the different chemical reactivity, rather than steric factors, strongly influences the activity.