83643-88-3 Usage
Uses
Used in Neuroscience Research:
(S)-AMPA is used as a research tool for studying the role of AMPA receptors in neuronal function and dysfunction. Its ability to induce apoptosis in cortical neurons makes it a valuable compound for investigating the mechanisms underlying neuronal cell death and potential therapeutic interventions.
Used in Drug Development:
(S)-AMPA is used as a lead compound in the development of drugs targeting AMPA receptors. Its agonistic properties can be leveraged to modulate glutamate receptor activity, which may have therapeutic potential in treating neurological disorders associated with glutamate dysregulation.
Used in Behavioral Studies:
(S)-AMPA has been used to activate the rostromedial tegmental nucleus (RMTg) in mice, providing insights into the neural mechanisms underlying aversive conditioning and its relation to cocaine-induced avoidance behaviors. This application aids in understanding the role of AMPA receptors in addiction and the development of potential treatments for substance abuse disorders.
Biological Activity
Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset? .
Biochem/physiol Actions
Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 83643-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,6,4 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 83643-88:
(7*8)+(6*3)+(5*6)+(4*4)+(3*3)+(2*8)+(1*8)=153
153 % 10 = 3
So 83643-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
