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AS1842856, also known as AS-1842856, is a potent inhibitor of forkhead box class O transcription factor 1 (FoxO1) with anti-obesity effects. It is a novel FoxO1 antagonist that can inhibit FoxO1-mediated transactivation, leading to a decrease in the expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA, and inhibit glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM). Additionally, AS1842856 inhibits 3T3-L1 preadipocyte differentiation and reduces lipid droplet growth in adipocytes.

836620-48-5

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836620-48-5 Usage

Uses

Used in Pharmaceutical Industry:
AS1842856 is used as a FoxO1 antagonist for its anti-obesity effects and potential treatment of type 2 diabetes mellitus (T2DM). By inhibiting FoxO1-mediated transactivation, it can decrease the expression of G6Pase and PEPCK mRNA, and inhibit glucogenesis, making it a promising candidate for the development of therapeutic agents targeting obesity and T2DM.

Check Digit Verification of cas no

The CAS Registry Mumber 836620-48-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,3,6,6,2 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 836620-48:
(8*8)+(7*3)+(6*6)+(5*6)+(4*2)+(3*0)+(2*4)+(1*8)=175
175 % 10 = 5
So 836620-48-5 is a valid CAS Registry Number.

836620-48-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name AS1842856

1.2 Other means of identification

Product number -
Other names 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:836620-48-5 SDS

836620-48-5Downstream Products

836620-48-5Relevant articles and documents

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

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Paragraph 00770; 00783-00784, (2020/08/22)

The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

QUINOLONE DERIVATIVE OR SALT THEREOF

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Page/Page column 24; 26, (2008/06/13)

A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.

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