83665-33-2

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(4-ethylphenyl)-
• CAS NO: 83665-33-2
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol File: 83665-33-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-ethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-ethylphenyl)-(83665-33-2)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(4-ethylphenyl)-(83665-33-2)

Safety Data

• Hazardous Substances Data: 83665-33-2(Hazardous Substances Data)

Upstream product

• 136918-14-4 phthalimide 
• 589-16-2 4-aminoethylbenzene 
• 100-41-4 ethylbenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 583-53-9 2,3-dibromobenzene 
• 85-44-9 phthalic anhydride 
• 895952-10-0 C₁₇H₁₃NO₄ 

Downstream Products

• 1532556-63-0 3-ethyl-2-(4-ethylphenyl)-3-hydroxyisoindolin-1-one 
• 1286261-71-9 2-ethyl-N-(4-ethylphenyl)benzamide 
• 589-16-2 4-aminoethylbenzene 
• 1875-48-5 N-aminophthalamide 
• 524-38-9 N-hydroxyphthalimide 
• 550-44-7 N-methylphthalimide 

Relevant articles and documents

Visible-Light-Induced Metal-/Photocatalyst-Free C-H Bond Imidation of Arenes

In this study, a visible-light-induced intermolecular C-H bond imidation of arenes was achieved at ambient condition. By using simple phthalimide with (diacetoxyiodo)benzene and molecular iodine, direct metal-/photocatalyst-free C-N bond formation was achieved. The imidation protocol was designed by using time-dependent density functional theory calculations and experimentally demonstrated for 28 substrates with as high as 96% yield. Mechanistic studies indicated that radical-mediated aromatic substitution occurred via photolysis of N-iodophthalimide under visible-light irradiation.

Palladium-catalyzed carbonylative synthesis of phthalimides from 1,2-dibromoarenes with molybdenum hexacarbonyl as carbon monoxide source

We describe here a convenient and mild, carbon monoxide gas-free palladium-catalyzed procedure to obtain N-substituted phthalimides with molybdenum hexacarbonyl as carbon monoxide precursor. These conditions tolerate a number of functional groups on the benzene ring as well as a number of amines and give the corresponding phthalimides in good to excellent yields. Copyright

Hypolipidemic Activity of Phthalimide Derivatives. 2. N-Phenylphthalimide and Derivatives

A series of substituted N-phenylphthalimide derivatives was synthesized and examined for their ability to lower serum cholesterol and triglyceride levels in mice at 20 (mg/kg)/day, ip.Of the newly synthesized compounds, the most potent compound, o-(N-phthalimido)acetophenone, lowered serum cholesterol 57percent after 16 days and lowered serum triglyceride levels 44percent after 14 days. o-(N-Phthalimido)acetophenone was observed to be active in both normogenic (normal blood lipids levels) and hyperlipidemic mice and normogenic rats.In the latter, the reduction of serum lipids was reversible.The mode of action of this compound appeared to be multiple, including blockage of the de novo synthesis of lipids and acceleration of the excretion of lipids.The lipoprotein fractions of rat blood were reduced significantly in cholesterol, triglyceride, and neutral lipid content after 14 days treatment with o-(N-phthalimido)acetophenone.