83670-90-0Relevant academic research and scientific papers
Additive-controlled regioselective direct asymmetric aldol reaction of hydroxyacetone and aldehyde
Liu, Ling-Yan,Wang, Bing,Zhu, Yunna,Chang, Wei-Xing,Li, Jing
, p. 533 - 542 (2013/06/27)
A structurally simple dipeptide derivative 1b prepared from l-proline and l-valine has been developed for the direct asymmetric aldol reaction of hydroxyacetone and various aldehydes with moderate to high yields and high enantioselectivities. More importa
Methods for the Stereoselective Cis Cyanohydroxylation and Carboxyhydroxylation of Olefins
Kozikowski, Alan P.,Adamczyk, Maciej
, p. 366 - 372 (2007/10/02)
Two valuable reagents for the cis-specific vicinal cyanohydroxylation and carboxyhydroxylation of olefins are described.The cyanohydroxylation process is based on the decarboxylative ring opening of 3-carboxyisoxazolines prepared by the cycloaddition reaction of carbethoxyformonitrile oxide with various alkenes.Fragmentation of the isoxazolines prepared from cis- and trans-2-butene has been found to occur without any crossover in stereochemistry.The carboxyhydroxylation process begins with the dipolar cycloaddition reaction of the nitrile oxide derived from thetetrahydropyranyl ether derivative of 2-nitroethanol.Deprotection, hydrogenation, and oxitative cleavage of the derived dihydroxy ketone yield the stereochemcally pure β-hydroxy carboxylic acid.
Methods for the Conversion of Isoxazolines to β-Hydroxy Ketones
Kozikowski, Alan P.,Adamczyk, Maciej
, p. 3123 - 3126 (2007/10/02)
Two methods have been developed for converting isoxazolines to β-hydroxy ketones in a stereospecific manner.
