837-63-8

Basic information

• Product Name: 2,1-benzoxazol-3-yl(phenyl)methanone
• Synonyms: Benzoylanthranil; Ketone, 2,1-benzisoxazol-3-yl phenyl
• CAS NO: 837-63-8
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.2268
• Mol File: 837-63-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 394.4°C at 760 mmHg
• Flash Point: 192.4°C
• Density: 1.256g/cm³
• Vapor Pressure: 1.98E-06mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 2,1-benzoxazol-3-yl(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1-benzoxazol-3-yl(phenyl)methanone(837-63-8)
• EPA Substance Registry System: 2,1-benzoxazol-3-yl(phenyl)methanone(837-63-8)

Safety Data

• Hazardous Substances Data: 837-63-8(Hazardous Substances Data)

Usage

Physical appearance

White to off-white crystalline powder.

Usage

Fluorescent probe for detecting hydroxyl radicals in biological and environmental systems.

Additional use

Spin trap for detecting free radicals.

Role

Precursor for the synthesis of various pharmaceutical and agrochemical compounds.

Application fields

Chemistry, biochemistry, and pharmaceutical research.

Safety precautions

Potential skin and eye irritation; harmful if swallowed or inhaled.

Upstream product

• 1969-74-0 2-phenylisatogen 
• 67-56-1 methanol 
• 14802-18-7 2-phenyl-1H-quinolin-4-one 
• 13141-38-3 2-phenylethynylaniline 
• 35010-17-4 1-nitro-2-phenylethynyl-benzene 
• 536-74-3 phenylacetylene 
• 535992-89-3 benzo[c]isoxazole-3-carbonyl chloride 

Downstream Products

• 850-59-9 benzo[c]isoxazol-3-yl-diphenyl-methanol 
• 58013-59-5 benzo[c]isoxazol-3-yl-phenyl-methanol 
• 24279-80-9 2,2',3,3'-tetrahydro-3,3'-dioxo-2,2'-diphenyl-2,2'-bi-1H-indole 
• 64968-22-5 3-acetoxy-2-phenylindole 
• 2989-63-1 2-phenyl-3H-indol-3-one 
• 31954-58-2 benzo[c]isoxazol-3-yl-phenyl-methanone oxime 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

Electrochemically Enabled Selenium Catalytic Synthesis of 2,1-Benzoxazoles fromo-Nitrophenylacetylenes

The study reported an electrochemically mediated method for the preparation of 2,1-benzoxazoles fromo-nitrophenylacetylenes. Different from the traditional electrochemical reduction of nitro to nitroso, the nitro group directly underwent a cyclization rea

Sequential Silver-Catalyzed Oxidative Cyclization Reactions of Unprotected 2-Alkynylanilines to Anthranils

The full details of the original Ag-catalyzed domino oxidative cyclization reactions of unprotected 2-alkynylanilines with Oxone are described. The influences of several parameters including the substrate features, oxidant, reaction conditions, and catalyst on the reaction outcome were explored. A plausible mechanism is provided for the unusual silver-catalyzed oxidative cyclization reactions of 2-alkynylanilines to anthranils.

Synthesis of α-diketones from alkylaryl- and diarylalkynes using mercuric salts

Both alkylarylalkynes and diarylalkynes 1 are converted into the α-diketones 2 in good yield by the use of mercuric salts, e.g., mercuric nitrate hydrate or mercuric triflate, in the presence of water. Other mercuric salts, e.g., sulfate, chloride, acetate, or trifluoroacetate, do not provide the diketone product. A possible mechanism is proposed.