83702-52-7

Usage

Uses

Used in Pharmaceutical Industry:
6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE is used as a building block for the synthesis of biologically active molecules for potential applications in drug development. Its unique structure and composition make it a promising candidate for the creation of antiviral or antitumor agents.
Used in Drug Development:
6-ACETYL-7-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE is used as a key component in the development of new pharmaceuticals. Ongoing research aims to explore its potential applications and biological activities, with a focus on its use in creating effective treatments for various diseases and conditions.

InChI:InChI=1/C10H8N4O/c1-6-9(7(2)15)5-12-10-8(3-11)4-13-14(6)10/h4-5H,1-2H3

Upstream product

• 16617-46-2 3-Amino-4-cyanopyrazole 
• 83702-51-6 6-acetyl-3-cyano-4,7-dihydro-7-methylpyrazolo<1,5-a>pyrimidine-7-carboxylic acid 
• 76963-66-1 5a-acetyl-6a-ethoxycarbonyl-5a,6a-dihydro-6H-cyclopropapyrazolo<1,5-a>pyrimidine-3-carbonitrile 
• 83702-50-5 Ethyl 6-acetyl-3-cyano-4,7-dihydro-7-methylpyrazolo<1,5-a>pyrimidine-7-carboxylate 

Downstream Products

• 130506-87-5 6-acetyl-3-cyano-7-(2-dimethylaminovinyl)pyrazolo<1,5-a>pyrimidine 

Relevant academic research and scientific papers

A NEW ENTRY TO PYRAZOLOPYRIMIDINE DERIVATIVES

Treatment of 3-aminopyrazoles (1a-e) with 3-ethoxymethylenpentane-2,4-dione afforded the new pyrazolopyrimidines (2a-e) which were then converted into the enamines (3a-e) by reaction with dimethylformamide dimethyl acetal; ring closure of these lat

Ring Transformation of 6H-Cyclopropapyrazolopyrimidine. IV (1). Reduction and Reaction of 5a-Acetyl-6a-ethoxycarbonyl-5a,6a-dihydro-6H-cyclopropapyrazolopyrimidine-3-carbonitriles with Primary Amines

The reaction of 5a-acetyl-6-ethoxycarbonyl-5a,6a-dihydro-6H-cyclopropapyrazolopyrimidine-3-carbonitrile (1a) with benzylamine gave ethyl 1-benzyl-5-cyano-8a,9-dihydro-2-methyl-1H-pyrrolo-pyrazolopyrimidine-8a-carboxylate (2a), in addition to 5-acetyl-3-benzylamino-1-(4-cyanopyrazol-3-yl)-2-pyridone (3).Reaction of 1a with aniline gave ethyl 6-acetyl-8-anilino-3-cyano-7,8-dihydro-4H-pyrazolodiazepine-8-carboxylate (4), in addition to etzhyl 3-cyano-7-methyl-6-pyrazolopyrimidineacrylate (5).On the other hand, the same reactions of 1b with benzylamine or aniline gave 2b or 8b,respectively.Though catalytic hydrogenation of 1a over 5percent palladium-carbon proceeded by ring fission of cyclopropane ring to give 9, 1a (or 1b) afforded 4,5-dihydro derivatives (13 or 15) by catalytic hydrogenation over platinum oxide. The reactivity of 5-methoxy-4,5,5a,6a-tetrahydro-6H-cyclopropapyrazolopyrimidine (16), which arerelated analogs of 1a,b, is also described.