83719-89-5Relevant academic research and scientific papers
Asymmetric tandem reduction of 2-(aroylmethyl)quinolines with phosphine-free Ru-TsDPEN catalyst
Wang, Tianli,Ouyang, Guanghui,He, Yan-Mei,Fan, Qing-Hua
supporting information; experimental part, p. 939 - 942 (2011/06/17)
The phosphine-free ruthenium complex containing chi-ral N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine (TsDPEN) showed excellent stereoselectivity in the tandem asymmetric reduction of 2-(aroylmethyl) quinolines. The reaction involves transfer hydrogenation of aromatic ketones and hydrogenation of quinolines, giving 1,2,3,4-tetrahydroquinoline derivatives with up to 99% ee and 95:5 dr. Georg Thieme Verlag Stuttgart · New York.
Syntheses of 1-Phenyl-2-(2-quinolyl)ethanones and Related Ethanones
Sund, Eldon H.,Lowe, William D.
, p. 137 - 138 (2007/10/02)
Seven 1-phenyl-2-ethanones were synthesized by the condensation of 2-methyl-6-substituted quinolines and methyl benzoate with sodium hydride as the condensing agent.Substituents in the 6 position were bromo, chloro, fluoro, methoxy, methyl, and trifluoromethyl as well as the parent compound.Picrate derivates were prepared from each ketone.
