83725-80-8

Upstream product

• 75-44-5 phosgene 
• 618-94-0 3-nitrobenzoic acid hydrazide 
• 329212-43-3 C₁₂H₁₅N₃O₄ 
• 1422157-57-0 N′-[chloro-(3-nitrophenyl)methylene]-tert-butylcarbazate 
• 99-61-6 3-nitro-benzaldehyde 
• 121-92-6 3-nitrobenzoic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 503-38-8 trichloromethyl chloroformate 
• 119933-30-1 C₁₂H₁₆N₄O₄ 

Downstream Products

• 115082-05-8 5-(3-amino-phenyl)-3H-[1,3,4]oxadiazol-2-one 
• 129221-13-2 N-(4-Benzyl-2,5-dioxo-imidazolidin-1-yl)-3-nitro-benzamide 
• 83725-84-2 N-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-3-nitro-benzamide 
• 1092114-74-3 3-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one 
• 115082-05-8 5-(3-aminophenyl)-1,3,4-oxadiazol-2-ol 

Relevant academic research and scientific papers

Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl- methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl- methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity.

PYRIMIDODIAZEPINONE DERIVATIVE

The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, R1 and R2 may be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH2)m (wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C=O, R3 represents a hydrogen atom, optionally substituted lower alkyl, or the like, and R4 represents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

THIAZOLE DERIVATIVES AND USE THEREOF

The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

Some 1-Aroyl-4,4-dialkylsemicarbazides and Their Cyclization to Afford 5-Aryl-1,3,4-oxadiazol-2(3H)-ones

Some 1-aroyl-4,4-dialkylsemicarbazides have been prepared by reacting aroyl-hydrazides with dimethyl- or diethyl-carbamoyl chloride.In boiling DMF they lose dimethylamine or diethylamine to give 5-aryl-1,3,4-oxadiazol-2(3H)-ones. - Keywords: 1-Aroyl-4,4-d

Synthesis of Substituted N-(2,4-Dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides and N-(2-Thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides

Substuted N-(2,3-dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (3a-g) and substituted N-(2-thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (4a-g) were synthetized in one step from the reaction of methyl anthranilate with 2-aryl-1,3,4-oxadiazolin-5-ones (1a-g) and 2-aryl-1,3,4-oxadiazoline-5-thiones (2a-g), respectively, in m-cresol at 150-160 deg C.Alternative routes leading to the formation of 3a and 4a are also reported.