83726-75-4

Basic information

• Product Name: 2-CHLORO-4-THIEN-2-YLPYRIMIDINE
• Synonyms: 2-CHLORO-4-THIEN-2-YLPYRIMIDINE
• CAS NO: 83726-75-4
• Molecular Formula: C₈H₅ClN₂S
• Molecular Weight: 196.6567
• Mol File: 83726-75-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 370.78°C at 760 mmHg
• Flash Point: 178.042°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-4-THIEN-2-YLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-THIEN-2-YLPYRIMIDINE(83726-75-4)
• EPA Substance Registry System: 2-CHLORO-4-THIEN-2-YLPYRIMIDINE(83726-75-4)

Safety Data

• Hazardous Substances Data: 83726-75-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-thien-2-ylpyrimidine is a chemical compound with the molecular formula C7H5ClN2S. It is a heterocyclic compound containing both a pyrimidine and a thienyl ring, as well as a chlorine substituent. 2-CHLORO-4-THIEN-2-YLPYRIMIDINE is often used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and potential for drug development. It is also a valuable building block in organic synthesis, being utilized in the construction of various biologically active molecules. 2-Chloro-4-thien-2-ylpyrimidine is an important chemical intermediate, with applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C8H5ClN2S/c9-8-10-4-3-6(11-8)7-2-1-5-12-7/h1-5H

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 188290-36-0 thiophene 
• 2786-07-4 2-thienyl lithium 
• 1722-12-9 2-chloropyrimidine 
• 6165-68-0 thiophene boronic acid 

Downstream Products

• 1114991-21-7 N-1,3-Thiazol-2-yl-4-[(4-thien-2-ylpyrimidin-2-yl)amino]benzenesulfonamide 
• 1227161-21-8 2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)benzoic acid 
• 115419-74-4 2-chloro-4-phenyl-6-(2-thienyl)pyrimidine 

Relevant articles and documents

Synthesis and antitumor activity of bithienyl-pyrimidine derivatives with electrostatic binding side chains

A series of bithienyl-pyrimidines having cationic side chain have been developed as antitumor agents. This work illustrates the overwhelming importance of the bithienyl unit for efficient DNA binding. The X-ray structure of 4-(2',2'-thien-5-yl)-2-chloropyrimidine was obtained for postulating the conformation of the bithienyl-pyrimidine moiety.

METHODS AND COMPOSITIONS OF INHIBITING DCN1-UBC12 INTERACTION

In one aspect, the invention relates to substituted l-phenyl-3-(piperidin-4-yl)urea analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the DCN1-UBC12 interaction inhibitors of DCN1 -mediated cullin-RING ligase activity, methods of making same, pharmaceutical compositions comprising same, methods of treating disorders using the disclosed compounds and compositions, methods of treating disorders associated with a DCN1-UBC12 interaction dysfunction, methods of treating disorders associated with a DCN1-mediated cullin-RING ligase activity dysfunction, methods of male contraception comprising the disclosed compounds and compositions, and kits comprising the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS

The present invention is concerned with diazaspiroalkanone- substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human a