83734-43-4

Usage

Uses

Used in Chemistry:
2-hydroxyquinoline-5-carboxylic acid is used as a chelating agent for metal complexation, facilitating the binding and separation of metal ions in chemical processes.
Used in Pharmaceutical Synthesis:
It serves as a precursor in the synthesis of various pharmaceuticals and organic compounds, playing a crucial role in the development of new drugs and medicinal agents.
Used in Antimicrobial Applications:
2-hydroxyquinoline-5-carboxylic acid is studied for its potential anti-microbial properties, offering a possible alternative for combating microbial infections.
Used in Anticancer Research:
2-hydroxyquinoline-5-carboxylic acid has been investigated for its anti-cancer properties, suggesting its potential use in the development of cancer treatments.
Used in Dye and Fluorescent Compound Formulation:
Leveraging its fluorescent properties, 2-hydroxyquinoline-5-carboxylic acid is utilized in the formulation of dyes and fluorescent compounds, finding applications in various industries that require colorants or fluorescence-based technologies.

Upstream product

• 83734-42-3 3-(3-ethoxyacryloylamino)benzoic acid 
• 83734-42-3 3-benzoic acid 
• 1092287-30-3 2-chloroquinoline-5-carboxylic acid 
• 99-05-8 meta-aminobenzoic acid 

Downstream Products

• 70758-34-8 methyl 2-oxo-1,2-dihydroquinoline-5-carboxylate 
• 88371-29-3 1,2,3,4-tetrahydro-2-oxo-5-quinolinecarboxylic acid 
• 106752-38-9 5-[4-(3-Oxo-3-phenyl-propyl)-piperazine-1-carbonyl]-1H-quinolin-2-one 
• 789444-14-0 5-(4-benzyl-1-piperazinylcarbonyl)-2(1H)-quinolinone 
• 90098-47-8 2-(4-Chloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-5-yl)-propionic acid 
• 72394-52-6 1,2,3,4-tetrahydro-2-oxo-quinoline-5-aldehyde 

Relevant academic research and scientific papers

Visible light-induced one-pot synthesis of CF3/CF2-substituted cyclobutene derivatives

An efficient one-pot approach for the controllable synthesis of trifluoromethyl/gem-difluoromethylene substituted cyclobutene derivatives has been developed. The mechanism may involve visible light-induced [2+2]-cycloaddition of quinolinones with 1-bromo-1-trifluoromethylethene, followed by base-promoted dehydrobromination, [1,3]-H shift and further dehydrofluorination. A variety of CF3/CF2-substituted cyclobutenes that are currently difficult to obtain are afforded in good yields in this protocol, which may find its way into future fluorinated cyclobutene preparation.

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to a novel inhibitor pharmacophore of PCSK9 and heteroaryl compounds that bind the PCSK9 protein.

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to novel heteroaryl compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.

Carbostyril derivatives

Disclosed are carbostyril derivatives and their salts of the formulas STR1 The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.