837364-65-5Relevant academic research and scientific papers
N,N′-carbonyldiimidazole-mediated cyclization of amino alcohols to substituted azetidines and other N-heterocycles
De Figueiredo, Renata Marcia,Froehlich, Roland,Christmann, Mathias
, p. 4147 - 4154 (2007/10/03)
Amino alcohols are important synthons for N-heterocycles. We have developed an efficient method to activate hydroxyl groups, which avoids the use of toxic reagents and tolerates a wide variety of functional groups. Our strategy has been applied to the syn
A Mannich-cyclization approach for the asymmetric synthesis of saturated N-heterocycles
Münch, Alexander,Wendt, Bianca,Christmann, Mathias
, p. 2751 - 2755 (2007/10/03)
A concise asymmetric synthesis of disubstituted N-heterocycles is reported. Our approach utilizes an optimized Mannich reaction of functionalized aldehydes, followed by a novel dehydrative cyclization mediated by the Staab reagent (1,1′-carbonyldiimidazol
