837430-11-2

Basic information

• Product Name: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,5-DIFLUOROPHENYL)PROPANOATE
• Synonyms: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,5-DIFLUOROPHENYL)PROPANOATE;methyl (2R)-3-(2,5-difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate;(R)-METHYL 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(2,5-DIFLUOROPHENYL)PROPANOATE
• CAS NO: 837430-11-2
• Molecular Formula: C₁₅H₁₉F₂NO₄
• Molecular Weight: 315.3124664
• Mol File: 837430-11-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• PKA: 10.79±0.46(Predicted)
• CAS DataBase Reference: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,5-DIFLUOROPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,5-DIFLUOROPHENYL)PROPANOATE(837430-11-2)
• EPA Substance Registry System: METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,5-DIFLUOROPHENYL)PROPANOATE(837430-11-2)

Safety Data

• Hazardous Substances Data: 837430-11-2(Hazardous Substances Data)

Upstream product

• 923601-71-2 2-tert-butoxycarbonylamino-3-(2,5-difluorophenyl)-acrylic acid methyl ester 
• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 837430-10-1 (2R,5S)-2,5-dihydro-3,6-dimethoxy-2-[(2',5'-difluorophenyl)methyl]-5-isopropylpyrazine 

Downstream Products

• 923564-19-6 [(1R,2S)-3-(3-tert-butylcarbamoyl-6-trifluoromethyl-pyridin-2-yl)-1-(2,5-difluoro-benzyl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 923564-18-5 [(R)-3-(3-tert-butylcarbamoyl-6-trifluoromethyl-pyridin-2-yl)-1-(2,5-difluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester 
• 923563-75-1 [(R)-2-(2,5-difluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 1026406-69-8 {1-(2,5-difluoro-benzyl)-3-oxo-3-[3-(2,2,2-trifluoro-ethyl)-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-propyl}-carbamic acid tert-butyl ester 
• 486460-22-4 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine 
• 486460-31-5 7-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine 
• 837430-13-4 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid methyl ester 
• 486459-98-7 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid 
• 837430-12-3 (R)-3-[(1,1-dimethylethoxycarbonyl)amino]-1-diazo-4-(2,5-difluorophenyl)butan-2-one 
• 261380-31-8 (R)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine 

Relevant articles and documents

1-AMINO LINKED COMPOUNDS

The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C2-C6 alkyl-O- C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C2-C6 alkyl, -C(O)R9 and -SO2R9, or R7 and R8 combine to form (III), (IV); W is selected from CRlO and CR15, RlO is selected from H, halo, -C(O)NR13R14, C1-C6 alkyl, aryl, heteroaryl, C1-C6 alkylaryl, C1-C6 alkylheteroaryl, C1-C6 alkyl-O- C1-C6 alkyl and hydroxy C1-C6 alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH3, CF3, aryl, heteroaryl, C1-C4 alkylaryl or C1-C4 alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.

PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS

The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (1); X is selected from CH, CF and N; R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalk