83747-12-0

Basic information

• Product Name: 1-TERT-BUTOXY-2-NITROBENZENE
• Synonyms: 1-TERT-BUTOXY-2-NITROBENZENE
• CAS NO: 83747-12-0
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 83747-12-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 286.1±13.0 °C(Predicted)
• Appearance: /
• Density: 1.116±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-TERT-BUTOXY-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTOXY-2-NITROBENZENE(83747-12-0)
• EPA Substance Registry System: 1-TERT-BUTOXY-2-NITROBENZENE(83747-12-0)

Safety Data

• Hazardous Substances Data: 83747-12-0(Hazardous Substances Data)

Usage

Appearance

Pale yellow solid This describes the physical appearance of the compound.

Molecular weight

191.21 g/mol This is the mass of one mole of the compound.

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, building block in the production of dyes, pigments, and other specialty chemicals This describes the common applications of the compound.

Toxicity

Low toxicity This indicates the level of danger the compound poses to living organisms. However, it is important to handle it with care and follow proper safety protocols.

Upstream product

• 507-20-0 tertiary butyl chloride 
• 88-75-5 2-hydroxynitrobenzene 
• 91-23-6 2-Nitroanisole 
• 865-48-5 sodium t-butanolate 
• 75-65-0 tert-butyl alcohol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 865-47-4 potassium tert-butylate 
• 30718-69-5 Benzyltrimethylammonium-t-butoxid 
• 609-73-4 o-nitroiodobenzene 
• 99-65-0 meta-dinitrobenzene 
• 98-95-3 nitrobenzene 

Downstream Products

• 1269631-73-3 sulfuric acid 1,4-bis-(4-hydroxy-phenyl)-2,5-dioxo-3-{2-[4-(2,2,2-trichloro-ethoxysulfonyloxy)-phenyl]-ethyl}-2,3,5,6-tetrahydro-pyrrolo[2,3-c]carbazol-7-yl ester 2,2,2-trichloro-ethyl ester 
• 1269631-70-0 Sulfuric acid 5-hydroxy-1,4-bis-(4-methoxy-phenyl)-3-{2-[4-(2,2,2-trichloro-ethoxysulfonyloxy)-phenyl]-ethyl}3,6-dihydro-pyrrolo[2,3-c]carbazol-7-yl ester 2,2,2-trichloro-ethyl ester 
• 1310146-45-2 3-(4-hydroxyphenethyl)-3,6-dihydro-5-methoxy-1,4-bis(4-methoxyphenyl)pyrrolo[2,3-c]carbazol-7-ol 
• 1269631-68-6 3-[4-(benzyloxy)phenethyl]-7-(tert-butoxy)-5-methoxy-1,4-bis(4-methoxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazole 
• 1310146-42-9 1-(4-(benzyloxy)phenethyl)-4-(3-tert-butoxy-2-azidophenyl)-6-methoxy-3,7-bis(4-methoxyphenyl)-1H-indole 
• 901121-70-8 dictyodendrin C 
• 1269631-76-6 sulfuric acid 5-hydroxy-1,4-bis-(4-hydroxy-phenyl)-3-[2-(4-hydroxy-phenyl)-ethyl]-3,6-dihydropyrrolo[2,3-c]carbazol-7-yl ester 2,2,2-trichloro-ethyl ester 

Relevant articles and documents

Total Synthesis of Dictyodendrins A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole

The total synthesis of dictyodendrins A–F was achieved by using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2,3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.

Total Synthesis of Dictyodendrins by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles

In total and formal syntheses of dictyodendrins B, C, E, and F, the key step involved the direct construction of the pyrrolo[2,3-c]carbazole core by the gold-catalyzed annulation of a conjugated diyne with a pyrrole to form three bonds and two aromatic rings. The subsequent introduction of substituents at the C1 (Suzuki–Miyaura coupling), C2 (addition to an aldehyde), N3 (alkylation), and C5 positions (Ullman coupling) provided divergent access to dictyodendrins.

Total synthesis of dictyodendrins A-E

A highly efficient total synthesis of dictyodendrins A-E was accomplished. The synthesis features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. Peripheral substituents were introduced onto this intermediate in a modular fashion to complete the total synthesis of dictyodendrins A-E. A benzyne-mediated one-pot indoline formation/cross-coupling sequence is used for the construction of a highly substituted common indole intermediate. The peripheral substituents were introduced using a Friedel-Crafts reaction on the indole intermediate in a modular fashion to complete the total synthesis. Copyright