83759-54-0

Basic information

• Product Name: neo-kyotorphin
• Synonyms: L-Arginine,N2-[N-[N2-(N-L-threonyl-L-seryl)-L-lysyl]-L-tyrosyl]-; Neokiotorphin;Neokyotorphin
• CAS NO: 83759-54-0
• Molecular Formula: C₂₈H₄₇N₉O₉
• Molecular Weight: 653.733
• Mol File: 83759-54-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.48g/cm³
• Refractive Index: 1.646
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: neo-kyotorphin(CAS DataBase Reference)
• NIST Chemistry Reference: neo-kyotorphin(83759-54-0)
• EPA Substance Registry System: neo-kyotorphin(83759-54-0)

Safety Data

• Hazardous Substances Data: 83759-54-0(Hazardous Substances Data)

Usage

General Description

Neo-kyotorphin is a peptide compound that is derived from kyotorphin, a naturally occurring brain peptide with pain-relieving properties. Discovered in 2014, neo-kyotorphin has been found to have a stronger analgesic effect than its predecessor, possibly due to its distinct chemical structure which allows it to pass through the blood-brain barrier more easily. Studies indicate it may have potential applications in the treatment of chronic pain conditions. As a synthetic peptide, it consists of two amino acids and has a molecular formula of C17H24N4O4.

InChI:InChI=1/C28H47N9O9/c1-15(39)22(30)26(44)37-21(14-38)25(43)34-18(5-2-3-11-29)23(41)36-20(13-16-7-9-17(40)10-8-16)24(42)35-19(27(45)46)6-4-12-33-28(31)32/h7-10,15,18-22,38-40H,2-6,11-14,29-30H2,1H3,(H,34,43)(H,35,42)(H,36,41)(H,37,44)(H,45,46)(H4,31,32,33)/t15-,18+,19+,20+,21+,22+/m1/s1

Upstream product

• 97186-06-6 Z(OMe)-D-Lys(Z)-Tyr-L-Arg(Tos)-OH 
• 4353-32-6 N^G-tosylargine 
• 86579-32-0 Z(OMe)-L-Ser-D-Lys(Z)-Tyr-L-Arg(Tos)-OH 
• 86579-31-9 Z(OMe)-Lys(Z)-Tyr-L-Arg(Tos)-OH 
• 86579-32-0 Z(OMe)-Thr-D-Ser-L-Lys(Z)-Tyr-L-Arg(Tos)-OH 
• 86579-32-0 Z(OMe)-Thr-L-Ser-D-Lys(Z)-Tyr-D-Arg(Tos)-OH 
• 97233-92-6 H-D-Arg(Tos)-OH 
• 97185-99-4 Z(OMe)-Lys(Z)-Tyr-D-Arg(Tos)-OH 
• 88419-43-6 [(S)-5-[(S)-1-Azidocarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-5-(4-methoxy-benzyloxycarbonylamino)-pentyl]-carbamic acid benzyl ester 
• 86579-32-0 Z(OMe)-Thr-D-Ser-L-Lys(Z)-Tyr-D-Arg(Tos)-OH 
• 86579-32-0 Z(OMe)-Thr-Ser-Lys(Z)-Tyr-D-Arg(Tos)-OH 

Relevant articles and documents

Diffusion based kinetic selectivity modulation of enzymatic proteolysis in a microfluidic reactor: Experimental analysis and stochastic modeling

Microreactors enable new experimental ways for enzyme engineering. In this context, we show that the liquid-liquid parallel laminar flows in microchannels cause a kinetic selectivity modification of proteolytic enzymatic reaction involving hemoglobin and pepsin, reaction that generates numerous bioactive peptides at different advancement state. Here we show that this diffusion based kinetic modulation induces an altered peptides appearance kinetics for a part of the initial substrate population. Indeed, microfluidic and conventional batch experiments performed in the same reaction conditions lead to strong differences in the resulting peptidic profiles obtained by reversed-phase high-performance liquid chromatography. Such differences are explained by the laminar flow diffusive conditions inside microchannels and are supported by a stochastic algorithm based on the Michaelis-Menten equation. Several bioactive peptides are identified by mass spectrometry and show the potential of such methodology in peptides screening from a complex proteolysis but also for selective peptides preparation by microfluidics.