83763-11-5 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-piperidinyl)-1H-benzimidazole is used as a histamine H3 receptor antagonist for its potential role in the treatment of cognitive impairments and neurodegenerative diseases. 1-(4-piperidinyl)-1H-benzimidazole's interaction with the histamine H3 receptor may offer neuroprotective and cognitive-enhancing effects, making it a candidate for further development in this therapeutic area.
Used in Psychiatric Treatment:
In the psychiatric field, 1-(4-piperidinyl)-1H-benzimidazole is considered for its potential therapeutic use in disorders such as schizophrenia. Its pharmacological profile suggests that it may help in managing the symptoms of these disorders by modulating neurotransmitter systems involved in their pathophysiology.
Used in Research and Development:
1-(4-piperidinyl)-1H-benzimidazole serves as a subject of ongoing research to explore its full range of biological activities. This includes investigating its interactions with various biological targets and assessing its safety and efficacy in preclinical and clinical studies, with the aim of identifying new avenues for its medicinal application.
Check Digit Verification of cas no
The CAS Registry Mumber 83763-11-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,6 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 83763-11:
(7*8)+(6*3)+(5*7)+(4*6)+(3*3)+(2*1)+(1*1)=145
145 % 10 = 5
So 83763-11-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H15N3/c1-2-4-12-11(3-1)14-9-15(12)10-5-7-13-8-6-10/h1-4,9-10,13H,5-8H2
83763-11-5Relevant academic research and scientific papers
DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS
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Page/Page column 7; 87-90, (2011/12/02)
Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.
New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
Frohn, Mike,Xu, Han,Zou, Xiaoming,Chang, Catherine,McElvaine, Michele,Plant, Matthew H.,Wong, Min,Tagari, Philip,Hungate, Randall,Buerli, Roland W.
, p. 6633 - 6637 (2008/03/18)
We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: Effects of fused heterocycles on antiviral activity and pharmacokinetic properties
Kim, Dooseop,Wang, Liping,Hale, Jeffrey J.,Lynch, Christopher L.,Budhu, Richard J.,MacCoss, Malcolm,Mills, Sander G.,Malkowitz, Lorraine,Gould, Sandra L.,Demartino, Julie A.,Springer, Martin S.,Hazuda, Daria,Miller, Michael,Kessler, Joseph,Hrin, Renee C.,Carver, Gwen,Carella, Anthony,Henry, Karen,Lineberger, Janet,Schleif, William A.,Emini, Emilio A.
, p. 2129 - 2134 (2007/10/03)
A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity.
