84176-75-0 Usage
Chemical class
Heterocyclic organic compound
Use
Antihistamine and antipruritic agent
Classification
Benzimidazole derivative
Mechanism of action
Selective antagonist of histamine H1 receptors
Potential applications
Treatment of allergies, allergic reactions, and skin conditions (itching and hives)
Chemical structure
Benzimidazole ring attached to a piperidine moiety
Pharmacological properties
Derived from the benzimidazole and piperidine structure
Binding affinity
Strong for histamine H1 receptors
Efficacy
Effectively blocks the action of histamine, providing relief from allergy symptoms
Check Digit Verification of cas no
The CAS Registry Mumber 84176-75-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,1,7 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 84176-75:
(7*8)+(6*4)+(5*1)+(4*7)+(3*6)+(2*7)+(1*5)=150
150 % 10 = 0
So 84176-75-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H21N3/c1-2-6-16(7-3-1)14-21-12-10-17(11-13-21)22-15-20-18-8-4-5-9-19(18)22/h1-9,15,17H,10-14H2
84176-75-0Relevant academic research and scientific papers
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: Effects of fused heterocycles on antiviral activity and pharmacokinetic properties
Kim, Dooseop,Wang, Liping,Hale, Jeffrey J.,Lynch, Christopher L.,Budhu, Richard J.,MacCoss, Malcolm,Mills, Sander G.,Malkowitz, Lorraine,Gould, Sandra L.,Demartino, Julie A.,Springer, Martin S.,Hazuda, Daria,Miller, Michael,Kessler, Joseph,Hrin, Renee C.,Carver, Gwen,Carella, Anthony,Henry, Karen,Lineberger, Janet,Schleif, William A.,Emini, Emilio A.
, p. 2129 - 2134 (2007/10/03)
A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity.
