83774-09-8

Basic information

• Product Name: 2-Chloro-4-ethoxypyrimidine
• Synonyms: 2-Chloro-4-ethoxypyrimidine;2-chloro-4-ethoxypyrimidine(SALTDATA: FREE);2-chloro-4-ethyloxypyriMidine
• CAS NO: 83774-09-8
• Molecular Formula: C₆H₇ClN₂O
• Molecular Weight: 158.58558
• Mol File: 83774-09-8.mol

Chemical Properties

• Melting Point: 35℃
• Boiling Point: 279℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.235
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-4-ethoxypyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-ethoxypyrimidine(83774-09-8)
• EPA Substance Registry System: 2-Chloro-4-ethoxypyrimidine(83774-09-8)

Safety Data

• Hazardous Substances Data: 83774-09-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-ethoxypyrimidine is used as a key intermediate for the synthesis of pyrimidine derivatives, which are vital in the development of various pharmaceuticals. These derivatives exhibit a wide range of biological activities, including antiviral, antibacterial, and anticancer properties, making them essential components in the formulation of life-saving drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-ethoxypyrimidine is employed as a precursor in the synthesis of pyrimidine-based agrochemicals. These compounds are used as pesticides, herbicides, and insecticides, playing a crucial role in protecting crops from pests and diseases, thereby ensuring food security and agricultural productivity.
Used in Antiviral and Antibacterial Agents:
2-Chloro-4-ethoxypyrimidine is utilized in the synthesis of antiviral and antibacterial agents, which are essential in combating infectious diseases. These agents target specific viral or bacterial processes, inhibiting their growth and spread, and providing effective treatment options for various infections.
Used in Research and Development:
Due to its unique chemical properties and reactivity, 2-Chloro-4-ethoxypyrimidine is also used in research and development for the discovery of new compounds and drug candidates. It serves as a valuable tool for chemists and researchers in exploring novel chemical reactions and developing innovative therapeutic agents.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 141-52-6 sodium ethanolate 
• 64-17-5 ethanol 

Downstream Products

• 24903-72-8 4-Aethoxypyrimidin 
• 145947-97-3 2-acetyl-4-ethoxypyrimidine 
• 145947-99-5 2-cyano-4-ethoxypyrimidine 

Relevant articles and documents

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

4-ethoxy-pyrimidines

4-Ethoxy-pyrimidines useful as intermediates in preparing antiviral 1,3-oxathiolane nucleosides are described.

2,4-Diamino-6,7-dimethoxyquinoline Derivatives as α1-Adrenoreceptor Antagonists and Antihypertensive Agents

A series of 2,4 -diamino-6,7-dimethoxyquinoline derivatives (2), prepared by LDA- or ZnCl2-mediated intramolecular cyclization of an N--2-cyano-4,5-dimethoxyaniline (3), was evaluated for α-adrenoreceptor affinity and antihyper

The Mechanism of Thermal Eliminations. Part 18. Relative Rates of Pyrolysis of 2-Ethoxypyrazine, 3-Ethoxypyridazine, 2-and 4-Ethoxypyrimidine, 3-Chloro-6-ethoxypyridazine, and 2-Chloro-4-ethoxypyrimidine : the Effect of the Aza 'Substituent' and ?-Bond Order on the Elimination Rate

A kinetic study has been made of the first-order thermal decomposition of the title compounds into ethylene and the corresponding aza-substituted pyridines, between 650 and 713 K.The relative elimination rates at 650 K are (2-ethoxypyridine = 1): 0.545, 10.0, 1.03, 1.12, 9.68, and 3.28, respectively.The electronic effects of the aza 'substituent' are small, and a more important factor appears to be the C-N ?-bond order; this latter accounts for the high reactivity of the pyridazines.The effects of the chloro substituent and of the aza 'substituent' are explicable in terms of a balance between electron withdrawal from the C-O bond (producing deactivation) and from the nitrogen involved in the cyclic transition state (producing deactivation).The effects of the chloro substituents confirm that the most important step of the reaction is breaking of the C-O bond.The statistically corrected rate (per ring nitrogen) of 2-ethoxypyrimidine is unexpectedly low.This may reflect difficulty in achieving the coplanar transition state in which the lone pairs in the s-orbitals of oxygen and the nitrogen not involved in the elimination are brought into close proximity.