83774-13-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-isopropoxypyrimidine is used as a key intermediate in the synthesis of pyrimidinyl-substituted thiazolidinediones. These compounds exhibit hypoglycemic and hypolipidemic activities, making them valuable for the development of drugs to treat diabetes and related metabolic disorders. The incorporation of this intermediate allows for the design of more effective and targeted therapies to manage blood sugar and lipid levels in patients.

InChI:InChI=1/C7H9ClN2O/c1-5(2)11-7-3-6(8)9-4-10-7/h3-5H,1-2H3

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 601482-40-0 4-(2-butynyloxy)-6-isopropoxypyrimidine 
• 869639-18-9 4-{2-[(6-isopropoxypyrimidin-4-yl)methylamino]ethoxy}benzaldehyde 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLOPYRIMIDINES AND SUBSTITUTED PURINES AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS

The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, X11, X12, R1, R3, R5, R5', R6, and R7 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to inhibit a USP1 protein and/or to treat a disorder responsive to the inhibition of USP1 proteins and USP1 activity. Compounds of the present disclosure are especially useful for treating cancer.

Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione

We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyr

PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES

The present invention relates to a pyrimidine compound of formula (1): wherein R1 is C3-C7 alkynyl; R2 is hydrogen, halogen, or C1-C3 alkyl; and R3 is C1-C8

4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives

2,4-Diaminoquinazoline compounds of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R is a pyrimidinyl, pyrazinyl, pyridazinyl or triazinyl group linked to the piperazine ring by one of its carbon atoms, and optionally substituted b