83803-82-1

Usage

Uses

4-(Chloromethyl)-N-isopropylbenzamide

InChI:InChI=1/C11H14ClNO/c1-8(2)13-11(14)10-5-3-9(7-12)4-6-10/h3-6,8H,7H2,1-2H3,(H,13,14)

Upstream product

• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 15572-56-2 isopropylamine hydrochloride 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 75-31-0 isopropylamine 

Downstream Products

• 90072-40-5 4-(2,5-Diamino-6-methyl-pyrimidin-4-ylsulfanylmethyl)-N-isopropyl-benzamide 
• 84439-83-8 4-(5-Amino-6-methoxy-pyrimidin-4-ylsulfanylmethyl)-N-isopropyl-benzamide 
• 90072-44-9 4-(6-Amino-3-oxy-pyrimido[5,4-d][1,2,3]triazin-8-ylsulfanylmethyl)-N-isopropyl-benzamide 
• 84439-87-2 5-(4-Isopropylcarbamoyl-benzylsulfanyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthetic method of procarbazide hydrochloride intermediate

The invention discloses a synthetic method of a procarbazide hydrochloride intermediate. The preparation method comprises the following step: in a solvent, in the presence of a hydrolysis agent, carrying out hydrolysis reaction as shown in the specification on a compound as shown in a formula II to obtain a compound as shown in a formula I. The preparation method disclosed by the invention has theadvantages of high yield, high purity and stable process, and is suitable for industrial production.

PYRAN DERVATIVES AS CYP11A1 (CYTOCHROME P450 MONOOXYGENASE 11A1) INHIBITORS

Compounds of formula (I) wherein R1, R2,R3,R4,R5,R23,R24,L, A and Bare as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1(CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroidreceptor, particularly androgen receptor,dependent diseases and conditions, such asprostate cancer.