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γ-Benzyloxyprotoporphyrin IX dimethyl ester (γ-BPDME) is a naturally occurring photosensitizer derived from the heme biosynthetic pathway. It is a lipophilic molecule that can be used in photodynamic therapy (PDT) for the treatment of various diseases, including cancer and certain skin conditions. γ-BPDME has a high absorption coefficient in the red region of the visible light spectrum, which allows for effective light activation and generation of reactive oxygen species (ROS) upon exposure to light. These ROS can cause cellular damage and lead to the destruction of targeted cells. The chemical structure of γ-BPDME consists of a protoporphyrin IX core with a benzyloxy group at the γ-position and two methyl ester groups at the propionic acid side chains. Its lipophilic nature enhances its ability to penetrate cell membranes and accumulate in target tissues, making it a promising candidate for PDT applications.

83807-57-2

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83807-57-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 83807-57-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,8,0 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83807-57:
(7*8)+(6*3)+(5*8)+(4*0)+(3*7)+(2*5)+(1*7)=152
152 % 10 = 2
So 83807-57-2 is a valid CAS Registry Number.

83807-57-2Downstream Products

83807-57-2Relevant academic research and scientific papers

Synthetic and Biosynthetic Studies of Porphyrins.Part 11.The Synthesis of meso Oxygenated Protoporphyrins.

Jackson, Anthony H.,Rao, K. R. Nagaraja,Wilkins,Martyn

, p. 307 - 312 (2007/10/02)

Treatment of protoporphyrin IX dimethyl ester (12) with benzoyl peroxideaffords a mixyure of the four isomeric meso-benzoiloxy derivaties (13) These have been separated by h.p.l.c. and distinguished from each other by hydrolysis to the corresponding oxophlorins (oxyporphyrins),insertionof iron to form the oxyhaems (3),and oxidation by molecular oxygen to the corresponding biliverdins (7).

Synthesis of the Four meso-Oxyprotoporphyrin Isomers

Jackson, Anthony H.,Rao, K. R. Nagaraja,Wilkins, Martyn

, p. 794 - 796 (2007/10/02)

The four isomers of meso-oxyprotoporphyrin dimethyl esters have been prepared via direct oxidation of protoporphyrin IX dimethyl ester, separated by h.p.l.c., and identified by conversion into the corresponding biliverdins.

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