83820-19-3Relevant articles and documents
Synthesis of Isothiazolopyridines
Mahalanabis, Kumar Kanti,Sarkar, Mili,Chattopadhyay
, p. 458 - 459 (2007/10/02)
3-Methyl-5-aminoisothiazole (II) undergoes facile condensation with ethyl ethoxymethylenemalonate (IIIa), ethyl ethoxymethyleneacetoacetate (IIIb), ethyl ethoxymethylenecyanoacetate (IIIc) and ethoxymethyleneacetylacetone (IIId) furnishing respectively the enamines IVa-d.IVa and IVb undergo thermal cyclisation to 3-methyl-4-hydroxy-5-ethoxy-carbonylisothiazolopyridine(Va) and 3-methyl-4-hydroxy-5-acetylisothiazolopyridine (Vb) respectively.