83822-34-8

Usage

Type

Synthetic chemical compound

Properties

Potential anti-cancer and anti-inflammatory properties

Function

Selective and potent inhibitor of the enzyme protein kinase D (PKD)

Involvement

Regulation of cell growth, proliferation, and survival

Studied for

Treatment of various cancers (breast, prostate, pancreatic) and inflammatory conditions

Promising results

Shown in preclinical studies

Investigated for

Reducing inflammation and promoting tissue repair in diseases such as rheumatoid arthritis and Crohn's disease

Interest

Development of novel therapeutic agents for cancer and inflammatory conditions

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 54153-19-4 2-cyano-N-m-tolylacetamide 
• 89733-15-3 α-(N-m-tolylcarboxamide)-α-cyclohexylidene acetonitrile 

Downstream Products

• 83822-28-0 3-m-Tolyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 1246527-88-7 3-N-(3-methylphenyl)-4,5-tetramethylene thieno-[2,3-d][1,2,3]-triazin-4(3H)-one 
• 197895-97-9 2-Chloromethyl-3-m-tolyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 197895-95-7 2-(2-Chloro-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid m-tolylamide 
• 85919-10-4 N-(3-m-Tolylcarbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-oxalamic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents

A series of 3-Substituted amino-4,5-tetramethylene thieno[2,3-d] [1,2,3]-triazine-4(3H)-ones have been synthesized and characterized by UV,IR, 1H NMR, elemental and mass spectral analysis. The title compounds were evaluated for their antimicrobial activit

Synthesis and evaluation of 2-chloromethyl-3-N-substituted arylthieno (2,3-d)pyrimidin-4-ones and derivatives for central nervous system depressant activity

2-Chloromethyl 3-N-substituted arylthieno (2,3-d)pyrimidin-4-ones and derivatives were synthesized by reacting 2-amino-3-carboxanilido-4,5,6,7-tetrahydrobenzo(b)thiophenes (I(abc)) with chloroacetyl chloride in dioxane and by cyclizing the open chain 3-su