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83863-47-2

83863-47-2

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83863-47-2 Usage

Chemical class

Piperidine derivative

Function

Potent and selective antagonist for the dopamine D4 receptor

Dopamine receptor family

Subtype of the dopamine receptor family

Therapeutic applications

Treatment of neurological and psychiatric disorders

Specific disorders

Schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder (ADHD)

Additional property

Analgesic properties

Potential use

Development of new pain management medications

Check Digit Verification of cas no

The CAS Registry Mumber 83863-47-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,8,6 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83863-47:
(7*8)+(6*3)+(5*8)+(4*6)+(3*3)+(2*4)+(1*7)=162
162 % 10 = 2
So 83863-47-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O.ClH/c20-17(19-11-5-2-6-12-19)15-9-13-18(14-10-15)16-7-3-1-4-8-16;/h1,3-4,7-8,15H,2,5-6,9-14H2;1H

83863-47-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (1-phenylpiperidin-1-ium-4-yl)-piperidin-1-ylmethanone,chloride

1.2 Other means of identification

Product number -
Other names KETONE,4-PHENYL-4-PIPERIDYL PIPERIDINO,HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83863-47-2 SDS

83863-47-2Downstream Products

83863-47-2Relevant articles and documents

Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists

Burkholder, Timothy P.,Kudlacz, Elizabeth M.,Maynard, George D.,Liu, Xiao-Gao,Le, Tieu-Binh,Webster, Mark E.,Horgan, Stephen W.,Wenstrup, David L.,Freund, David W.,Boyer, Fred,Bratton, Larry,Gross, Raymond S.,Knippenberg, Robert W.,Logan, Deborah E.,Jones, Bryan K.,Chen, Teng-Man,Geary, Julie L.,Correll, Melinda A.,Poole, J. Chuck,Mandagere, Arun K.,Thompson, Thomas N.,Hwang, Kin-Kai

, p. 2531 - 2536 (2007/10/03)

We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors. Here we report the synthesis and structure-activity relationships for a series of analogs of MDL 105,212 with regards to: NK1 and NK2 receptor binding affinity, physical-chemical characterization; in vitro absorption potential; in vitro metabolic stability; and efficacy in a capsaicin-challenge conscious guinea pig model after oral administration.

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