83867-61-2Relevant academic research and scientific papers
Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols
Ganiu, Moshood O.,Cleveland, Alexander H.,Paul, Jarrod L.,Kartika, Rendy
, p. 5611 - 5615 (2019/08/01)
The utility of triphosgene and DMAP as mild reagents for chemoselective dehydration of tertiary alcohols is reported. Performed in dichloromethane at room temperature, this reaction is readily tolerated by a broad scope of substrates, yielding alkenes preferentially with the (E)-geometry. While formation of the Hofmann products is generally favored, a dramatic change in alkene selectivity toward the Zaitzev products is observed when the reaction is carried out in dichloroethane at reflux.
Kinetics of elimination reactions of cumyl chloride and its substituted derivatives in acetonitrile
Balachandran,Santhosh Kumar
, p. 1731 - 1734 (2007/10/03)
A cent per cent unimolecular elimination reaction of tertiary aralkyl halides in acetonitrile is being reported for the first time. The reversibility in the rate determining step can be prevented by the addition of a weak base like pyridine in cumyl chloride and its α- and p-substituted derivatives. A plot of logarithmic rate constants of α-substituted cumyl chloride against Charton's steric parameter 'v' gives a linear relationship.
