83873-54-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 85027-68-5 (2S-trans)-N-<2-(acetyloxy)-4-oxo-3-azetidinyl>benzeneacetamide 
• 83873-53-4 (3S,4S)-4-acetoxy-3-amino-1-t-butyldimethylsilyl-2-oxoazetidine 
• 103-80-0 phenylacetyl chloride 
• 269742-76-9 (3S,4S)-3-N-(Benzyloxycarbonyl)-3-N-(phenylacetoxy)amino-4-acetoxyazetidin-2-one 
• 199385-33-6 (3S)-3-N-(Benzyloxycarbonyl)-3-N-(phenylacetoxy)aminoazetidin-2-one 

Downstream Products

• 34103-69-0 (1E,5R)-3-Phenylmethyl-4-thia-2,6-diazabicyclo[3.2.0]hept-2-en-7-one 

Relevant academic research and scientific papers

A total synthesis of (1R,5R)-3-phenylmethyl-4-thia-2,6-diazabicyclo [3.2.0]hept-2-en-7-one, a useful intermediate for the preparation of penem and cepham derivatives

The preparation of the thiazoline (1R,5R)-3-phenylmethyl-4-thia-2,6- diazabicyclo [3.2.0]hept-2-en-7-one (1) is presented. This compound, which has been extensively used as an intermediate for the synthesis of penems and cephams, has been obtained starting from a C-4 unsubstituted azetidinone by means of facile processes while chirality has been obtained through enzymatic resolution.

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R is hydrogen, R or R4 where R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or Beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals

1-SULFO-2-OXOAZETIDINE DERIVATIVES AND THEIR PRODUCTION

Disclosed are compounds of the general formula: wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R" is hydrogen, R or R4 wherein R is an organic residue attached to the azetidine ring through a carbon atom therein and R4 is azido, a halogen, an amino group which may optionally be acylated or a group of the formula ?OR5, or ?S-S-R5 wherein R5 is an organic residue and n is 0, 1 or 2, and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or beta-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals